NCT03458091已完成不适用
Evaluation of Lung Atelectasis During Apneic Oxygenation Using Trans Nasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) in Adults During Laryngeal Surgery.
Karolinska University Hospital1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2018年1月22日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Electrical impedans tomography
研究概览
简要总结
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as lung atelectasis and inflammatory stress response before implementing it into clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults, >18 years old.
- •ENT-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery).
- •Capable of understanding the study information and sign the written consent.
排除标准
- •Pacemaker or ICD.
- •Manifest cardiac failure or coronary disease
- •Severe gastrointestinal reflux.
- •Neuromuscular disorder
结局指标
主要结局
Electrical impedans tomography
时间窗: baseline, intraoperative, 2 hours after start of intervention
Changes in lung volumes
次要结局
- Difference in Endtidal and arterial carbon dioxide partial pressure in the end of the procedure(max 30 minutes after start of intervention)
- Increase in arterial carbon dioxide during the apnea(max 30 minutes after start of intervention)
研究者
Malin Jonsson Fagerlund
Senior Consultant, Associate Professor
Karolinska University Hospital
研究点 (1)
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