GnRHa Trigger in Asian Oocyte Donors Co-treated With a GnRH Antagonist - a Dose Finding Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 165
- 试验地点
- 1
- 主要终点
- Number of mature oocytes
研究概览
简要总结
The aim of this randomized single center study is to explore the most optimal dose of GnRHa used for triggering of final oocyte maturation in IVF. The study group will consist of oocyte donors who have GnRHa trigger as a standard trigger concept.
Hypothesis: In an Asian oocyte donor population, the use of 0.2 mg, 0.3mg or 0.4 mg of GnRHa will lead to the retrieval of comparable numbers of mature oocytes (MII) and good quality embryos. Moreover, the reproductive outcome in the recipients will be similar regardless of the dose of GnRHa used for trigger.
详细描述
Methods
A randomized controlled single center study. All oocyte donors, fulfilling the inclusion criteria, will be eligible for inclusion after randomization.
Stimulation, monitoring, oocyte pick-up in donors and embryo transfer in recipients On day two of the cycle, - i.e. prior to commencing stimulation with long acting FSH (Elonva) - donors will be randomized to one of three groups, using different doses of GnRHa (Triptorelin) for trigger. Stimulation will be performed according to the standard stimulation protocol of the clinic, using Elonva followed by co-treatment with a GnRH antagonist from day 5 of stimulation . The dose of Elonva used for stimulation will be either 100 or 150 µg according to the weight of the patient. The first transvaginal ultrasound scan (TVUS) will be performed after seven or eight days after the Elonva depot injection. As soon as two follicles have reached a size of ≥ 17mm, triggering of final oocyte maturation will be performed with one single bolus of Triptorelin, 0.2 mg, 0.3mg or 0.4 mg. The timing of the trigger will be 6 AM for all groups and the oocyte pick-up (OPU) will be performed after 34 hours, according to the usual practice of the clinic. Importantly, each patient will be asked to check the presence of an LH surge via a urine LH detection kit at 4 hours after the trigger bolus has been administered. Embryo transfer will be performed on day two in all recipients.
Study group I Stimulation according to the abovementioned and ovulation trigger with 0.2mg Triptorelin. All other procedures will be performed according to the practice of the clinic.
Study group II Stimulation according to the abovementioned and ovulation trigger with 0.3mg Triptorelin. All other procedures will be performed according to the practice of the clinic.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Oocyte donors who meet the following criteria:
- •Age 18 - 35
- •BMI < 28kg/m2
- •Normal ovarian reserve, defined by AMH > 1.25 ng/ml or AFC ≥ 6 measured within two months prior to stimulation start
- •Receiving GnRH-antagonist protocol for ovarian stimulation,
- •Agreement to participate in the study, and to disclose any medical events to the investigator. The subject must be willing and able to comply with the protocol requirements for the duration of the study.
- •Have given written informed consent with the understanding that the subject may withdraw consent at any time without prejudice to future medical care.
排除标准
- •Previous poor response (≤ 3 oocytes) after high dose FSH stimulation
- •Chronical medical conditions like Diabetes, Crohns disease, Thyroid disease, Hepatitis B and Sexually Transmitted Diseases Simultaneous participation in an interventional clinical trial.
- •Concommitant use of either LH or hMG/uFSH preparations in study cycle
研究组 & 干预措施
0.2mg Triptorelin
Ovulation trigger with 0.2mg Triptorelin in one subcutaneous injection.
干预措施: Triptorelin (Drug)
0.3mg Triptorelin
Ovulation trigger with 0.3mg Triptorelin in one subcutaneous injection.
干预措施: Triptorelin (Drug)
Active Comparator: 0.4mg Triptorelin
Ovulation trigger with 0.4mg Triptorelin in one subcutaneous injection.
干预措施: Triptorelin (Drug)
结局指标
主要结局
Number of mature oocytes
时间窗: 30 minutes after oocyte retrieval completed
次要结局
- Day of bleeding after oocyte pick-up(in 2 weeks after oocyte pick-up)
- Clinical pregnancy(5 weeks after oocyte pick-up)
研究者
Manh Tuong Ho
Doctor
Vietnam National University