NCT02434783已完成不适用
The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- mitochondrial respiratory capacity
研究概览
简要总结
Current evidence cannot explain the clinical features of peripheral arterial disease only from the principle of reduced blood flow. Explanations have therefore in addition been linked to mitochondrial dysfunction of skeletal muscles.
This study will elucidate whether there is a relation between clinical variables of the different levels of arterial insufficiency in peripheral arterial disease and mitochondrial respiratory capacity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Asymptotic peripheral arterial disease (Ankle-brachial index < 0.9), intermittent claudication (Ankle-brachial index 0.4 - 0.9), or critical limb ischemia (Ankle-brachial index < 0.4)
排除标准
- •Diagnosed with intermittent claudication secondary to vascular insufficiency
- •Warfarin or heparin usage
- •Underwent a vascular intervention in the last 6 months
- •Active cancer, renal- or liver disease
结局指标
主要结局
mitochondrial respiratory capacity
时间窗: 1 hour
measured in oxygen glux in pmol.s-1.mg-1, using mitochondrial respirometry on an Oxygraph-2k (Oroboros Instruments, Austria).
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Etiology and Prevalence of Peripheral Arterial DiseaseCardiovascular DiseasesPeripheral Vascular DiseasesArterial Occlusive DiseasesNCT00005142National Heart, Lung, and Blood Institute (NHLBI)
已完成
不适用
Mechanisms of Disability in Peripheral Arterial DiseaseCardiovascular DiseasesArterial Occlusive DiseasesPeripheral Vascular DiseasesNCT00046592National Heart, Lung, and Blood Institute (NHLBI)
已完成
不适用
Genetics of Peripheral Artery GenomicsPeripheral Artery DiseaseNCT00615121Duke University122
已完成
不适用
Prevalence of peripheral arterial disease in patients with coronary artery diseaseperipheral arterial disease (peripheral artery disease of lower limb, renal artery stenosis, carotid artery stenosis and abdominal aortic stenosis)JPRN-UMIN000002486Kokura Memorial Hospital2,000
已完成
不适用
Peripheral Vascular Disease and Coronary Artery DiseaseAcute Coronary SyndromeNCT03971864Harbin Medical University350