Clinical Outcomes of Patients With Deferred Revascularization Based on Fractional Flow Reserve (FFR) and Instantaneous Wave-free Ratio (iFR) Negative Coronary Artery Lesions in Pakistani Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 345
- 试验地点
- 1
- 主要终点
- Non-fatal myocardial infarction
研究概览
简要总结
The objective is to assess long-term clinical outcomes of patients in whom intervention of coronary lesions was deferred due to negative fractional flow reserve (FFR) and negative Instantaneous wave-free ratio (iFR) in a real-world patient population and to identify factors associated with deferred target lesion failure.
详细描述
Fractional flow Reserve (FFR) evaluates functional significance of stenosis in intermediate coronary lesions. Instantaneous wave-free ratio (iFR) is considered noninferior to FFR and does not require adenosine administration.
This study was done to assess long-term clinical outcomes and factors associated with target vessel revascularization (TVR) in patients with deferred revascularization based on negative FFR and iFR.
Retrospective analysis of medical records of 345 patients with deferred revascularization at a tertiary care hospital , from January 2012 to January 2020 will be done.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who had intermediate to severe coronary lesions on coronary angiogram.
- •Patients who had negative FFR >0.80 or iFR >0.89 and did not undergo immediate or planned revascularization on basis of negative physiologic assessment.
排除标准
- •Patients younger than 18 years of age or those having positive FFR/iFR values irrespective of revascularization status were excluded.
- •Similarly, those who were lost to follow up and could not be traced via telephonic or were also excluded.
结局指标
主要结局
Non-fatal myocardial infarction
时间窗: 29 months
Number of patients suffering from Myocardial infarction but did not die.
Cardiac death
时间窗: 29 months
Number of participants who died due to sudden cardiac arrest, sudden death due to acute MI and death due to heart failure or cardiogenic shock
Target vessel revascularization.
时间窗: 29 months
Repeat PCI or bypass graft placement for a stenosis in another part of the vessel treated at the index PCI
次要结局
未报告次要终点
研究者
Jamshed Ali
Resident, Section of Cardiology, Department of Medicine
Aga Khan University Hospital, Pakistan