NL-OMON29030招募中不适用
Glymphatic dysfunction in cognitive impairment: a memory clinic study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 120
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Patients with mild Alzheimer's disease dementia, patients with mild cognitive impairment (MCI), and healthy subjects will be included.
- •In order to be eligible for the AD dementia-group, a subject must meet all of the following criteria:
- •- Mentally competent (MMSE=18) and able to give informed consent
- •- Informed consent before participation in the study
- •- Age > 55 years
- •- Diagnosis of dementia of the AD type
- •Criteria for the MCI-group:
- •- Mentally component (MMSE =18) and able to give informed consent
- •- Informed consent before participation in the study
- •- Age > 55 years
- •- Diagnosis of MCI or diagnosis of Mild Neurocognitive Disorder (DSM V)
- •Criteria for the control (cognitively normal) group:
- •- Mentally component (MMSE =18) and able to give informed consent
- •- Informed consent before participation in the study
- •- Age > 55 years
- •- MMSE = 26
- •- Average age and gender is similar to the patient groups
排除标准
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •- Any significant disease or unstable medical condition that could influence neuropsychological testing (with the exception of a MCI or AD diagnosis)
- •- Major depression (according to the DSM IV) (< 12 months ago)
- •- Psychiatric history (schizophrenia, schizoaffective disorder, bipolar disorder or any history of electroconvulsive therapy)
- •- Vascular dementia
- •- Ischemic or valvular heart disease or electrocardiographic evidence of atrial fibrillation
- •- Recent transient ischemic attacks and ischemic or haemorrhagic stroke or cerebrovascular accident (< 2 years or paired with cognitive decline within 3 months after incident)
- •- Obstructive sleep apnoea syndrome
- •- Normal Pressure Hydrocephalus, M. Huntington, Parkinson’s disease, Frontotemporal dementia, Motor neuron diseases, Multiple sclerosis, Epilepsy
- •- Systemic inflammation, such as active rheumatoid arthritis
- •- Diabetes
- •- Cognitive impairment due to alcohol/drug abuse
- •- Structural abnormalities of the brain, such as tumours or stroke lesions
- •- Inability to provide informed consent
- •- Any contraindication for MRI: metallic implants, pacemaker, claustrophobia, pregnancy, tattoos in the head/neck region
- •- Unwillingness to be informed about potential abnormal MRI-findings
- •Additional exclusion criteria for the control group:
- •- A known diagnosis of mild cognitive impairment, prodromal dementia or dementia
- •- Substantial memory complaints (according to participant)
研究者
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