Negative Postprandial Effect on Endothelium After a Not-healthy Meal in Type 2 Diabetes as Affected by Training
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- endothelial function
研究概览
简要总结
The purpose of this study is to examine whether exercise reduces the postprandial effects of an unhealthy meal on heart function and endothelial function.
Both healthy people and type 2 diabetes subjects will during three days either carry out two different sessions of exercise training or not before ingesting an unhealthy meal high in saturated fat and fast carbohydrates. The two different exercise training modes used are high intensity interval training (HIIT) and moderate intensity training (MIT) Hypothesis: Exercise training in advance of an unhealthy meal will improve endothelial- and cardiac function in healthy and type 2 diabetes individuals. HIIT will reduce the negative postprandial effects on the endothelium more than MIT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •healthy or type 2 diabetes
排除标准
- •type 2 diabetes more than 10 years
- •unstable angina
- •myocardial infarction
- •overt cardiovascular disease.
- •severe valvular disease.
- •overt lung disease.
- •orthopedical- /neurological restrictions
- •severe disease related to diabetes type 2 (neuropathy, micro-or macroalbuminuria, retinopathy)
- •body mass index >35
- •severe eating disorders.
- •personality disturbances.
- •planned surgery during the project period.
- •patients who achieve greater than the current exercise guidelines for type 2 diabetes (210 min/week) before the start of the study.
- •uncontrolled hypertension
- •kidney failure
- •cardiomyopathy
- •patients who probably not will be able to complete the study
- •alcohol or drug abuse
结局指标
主要结局
endothelial function
时间窗: 24 hours
measured as flow mediated dilatation (FMD) of the brachial artery using high resolution vascular ultrasound according to current guidelines
次要结局
未报告次要终点