The Role of Exercise Training in the Treatment of Resistant Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 4
- 主要终点
- Ambulatory blood pressure
研究概览
简要总结
The main purpose of this study is to assess whether exercise training reduces ambulatory blood pressure in patients with resistant hypertension. To accomplish these goals 60 patients with resistant hypertension will be recruited and randomized into exercise training or control groups and followed up for 6 months. The patients in the exercise group will participate in a 3-month outpatient program. The control group will receive usual medical care. At baseline, after the intervention and 3 months after the end of the intervention both groups will undergo several evaluations, including casual and ambulatory blood pressure, body composition, cardiorespiratory fitness, quality of life, arterial stiffness, autonomic function, and endothelial and inflammatory biomarkers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •confirmed resistant hypertension, who in the previous 3 months had unchanged medication
排除标准
- •Patients with secondary hypertension
- •Evidence of target organ damage
- •Patients with heart failure
- •Previous cardiovascular event
- •Peripheral artery disease
- •Renal failure
- •Chronic obstructive pulmonary disease
- •Systolic office blood pressure superior to 180 mmHg
- •Biomechanical limitations to physical activity
- •Those participating in regular physical activity
结局指标
主要结局
Ambulatory blood pressure
时间窗: Change from Baseline in Blood Pressure at 3 months
Blood pressure
次要结局
- Arterial stiffness(Change from baseline to 3 months)
- Heart rate variability(Change from baseline to 3 months)
- Inflammation(Change from baseline to 3 months)
- Oxidative stress(Change from baseline to 3 months)
- Circulating number of endothelial progenitor cells, circulating endothelial cells, nitric oxide and endothelial Nitric Oxide Synthase(Change from baseline to 3 months)
- Daily physical activity(Change from baseline to 3 months)
- Casual blood pressure(Change from baseline to 3 months)
- Dietary intake(Change from baseline to 3 months)
- VO2 max(Change from baseline to 3 months)
- Body composition(Change from baseline to 3 months)
- Health-related quality of life(Change from baseline to 3 months)
研究者
Fernando Ribeiro
Adjunct Professor
Aveiro University