相关临床试验
509
140 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1961
进行中（未招募）
39
7.7%
已完成
244
47.9%
Enrolling By Invitation
25
4.9%
尚未招募
76
14.9%
招募中
85
16.7%
Unknown
40
7.9%
暂无批准数据
- A validated DLLME-LC-MS/MS method quantified plasma 5-hydroxyindoleacetic acid (5-HIAA) with 95.1% extraction recovery and a 5 ng/mL lower limit of quantification. - Plasma 5-HIAA was significantly elevated in 17 patients with major depressive disorder (25.73 ng/mL) versus 20 healthy controls (17.35 ng/mL), a roughly 48% increase. - ROC analysis yielded an area under the curve of 0.985, with 88.20% sensitivity and 100% specificity at a 21.93 ng/mL cutoff. - Plasma 5-HIAA correlated strongly with depression severity (r = 0.791), supporting its potential as both a diagnostic and severity biomarker.
- A WHO-supported cohort study of 1,230 Egyptian healthcare workers found COVID-19 vaccines demonstrated 68% effectiveness against symptomatic RT-PCR confirmed infections, though results were not statistically significant due to limited case numbers. - The study revealed that 99.8% of participants were seropositive for COVID-19 antibodies at enrollment, with all unvaccinated workers showing evidence of prior infection, highlighting widespread exposure in healthcare settings. - Healthcare workers with hybrid immunity (vaccination plus prior infection) showed enhanced protection with 89% vaccine effectiveness, while mRNA vaccines appeared superior to inactivated vaccines in preventing breakthrough infections. - Despite breakthrough infections occurring in 83.3% of positive cases among vaccinated workers, no hospitalizations or deaths were recorded, consistent with milder Omicron variant outcomes during the study period.
