相关临床试验
404
35 进行中
药物批准
0
批准总数
监管机构
0
监管机构数
成立时间
1583
进行中（未招募）
21
5.2%
已完成
286
70.8%
Enrolling By Invitation
4
1.0%
尚未招募
10
2.5%
招募中
53
13.1%
终止
13
3.2%
Unknown
5
1.2%
撤回
12
3.0%
暂无批准数据
- An international research team identified the EFEMP1 p.Arg140Trp variant as the cause of a previously unrecognized inherited retinal degeneration affecting peripheral and night vision. - The newly described condition, provisionally termed EFEMP1-associated late-onset retinal degeneration (L-ORD), was found in three unrelated families across multiple countries. - Rod photoreceptor dysfunction can be detected before visible structural retinal damage, providing a functional marker at a stage when photoreceptor cells remain intact. - Researchers do not yet know how widespread the variant is and say larger studies are needed to determine its prevalence and patient population size.
- A 14-day wearable ECG monitor fitted within 72 hours of A&E attendance more than doubled detection of clinically significant arrhythmias (22% vs. 9%) in 2,233 patients with unexplained syncope. - One-year all-cause mortality was nearly halved in the monitoring group (1.5% vs. 2.9%), alongside earlier diagnosis (median 22 vs. 55 days) and higher rates of pacemaker implantation and anti-arrhythmic therapy. - The primary endpoint of recurrent syncope showed no significant difference (1.37 vs. 1.58 episodes; IRR 0.89; 95% CI 0.68–1.18; p=0.43), but researchers argue the survival benefit supports routine ED use. - Findings from the ASPIRED trial, led by the University of Edinburgh and funded by the British Heart Foundation, were presented at ESC Congress 2026 and published in the New England Journal of Medicine.
- The Sustainable Aquaculture Innovation Cluster (SAIC) has appointed 14 international experts to a new science panel to guide its research and innovation funding decisions. - The panel, chaired by Pieter van West of the University of Aberdeen, spans fish and shellfish health, environmental science, veterinary medicine, seaweed, and technology. - The appointments coincide with SAIC's first full funding call since becoming independent from the University of Stirling, launched on 24 August. - SAIC secured £1.4 million in annual funding for at least five years from Crown Estate Scotland, supporting its relocation to the Highlands.
- Researchers at the Universities of Edinburgh and Bristol mapped a causal molecular chain linking a collagen IX gene defect to intervertebral disc degeneration in zebrafish, published in Communications Biology on July 28, 2026. - The osteoporosis drug class bisphosphonates and calorie restriction both reduced pathological mineral buildup and vertebral fusion in the zebrafish model by interrupting disrupted phosphate and lipid metabolism pathways. - No pharmacological treatment currently exists for IVDD, which affects 619 million people globally and is projected to reach 843 million by 2050, leaving surgery as the only long-term option. - Because bisphosphonates like alendronate are already FDA-approved with extensive safety data, the regulatory path to clinical trials for disc disease is shorter than for novel compounds, though mammalian validation remains necessary.
- A reparative neutrophil subpopulation releases the signaling molecule Il-4 to restrain destructive inflammation after spinal cord injury in larval zebrafish. - Disabling these neutrophils caused excessive inflammatory protein production, halted nerve fiber regrowth and impaired recovery of normal movement in the fish. - Directly supplying Il-4 to the injury site restored complete spinal cord regeneration even when the neutrophils were absent. - Researchers caution it remains unknown whether Il-4 plays a comparable role in human spinal cord repair, calling it a promising avenue for future study.
- A landmark genetic study of Scottish Travellers identified five rare recessive pathogenic variants with up to 2,500-fold enrichment compared to non-Finnish Europeans, including variants causing kidney disease and congenital myasthenic syndrome. - Researchers from the University of Edinburgh found that full Scottish Travellers carry an average of 84.9 Mb of runs of homozygosity, over 30 times higher than the mainland British population, consistent with a history of endogamy and recent consanguinity. - The study confirmed Scottish Travellers are genetically distinct from Irish Travellers and European Roma, with indigenous Scottish origins and two internal genetic subclusters reflecting Highland and Lowland ancestries. - Community-led genetic screening and clinician awareness are urgently needed, as 84% of participants carried two or more different recessive actionable variants, elevating the risk of severe Mendelian disorders.
- Scientists from Edinburgh, Glasgow, and Peking universities have compiled the most comprehensive catalogue of human-infective RNA viruses, identifying 239 species known to infect humans. - The dataset reveals that two to three new human-infecting viruses are still discovered annually, with 90% of RNA viruses also found in non-human animal reservoirs. - Only 60 species are capable of sustained human-to-human transmission, and a subset of outbreak viruses has proven to be a powerful predictor of public health emergencies. - Researchers emphasize the catalogue can help identify which viruses pose the greatest risk, including potential "Disease X" candidates, to strengthen global surveillance and pandemic preparedness.
- Researchers identified a previously unrecognised lung-specific form of the DPP9 enzyme carrying a genetic variant linked to severe COVID-19 and lung fibrosis. - The variant rs12610495 alters the function of this hidden protein, which had remained overlooked because it is absent from standard reference genome databases. - The study combined large genetic datasets with long-read RNA sequencing and computational modelling across 22 tissues to map disease-associated variants to alternative protein forms. - Findings suggest many disease-linked genetic changes act through previously hidden proteins, opening new opportunities for diagnosis and therapeutic targeting.
- Researchers developed biohybrid magnetic microbots from natural microalgae that deliver chemotherapy directly into bladder tumors with real-time ultrasound guidance. - In mouse studies, the approach increased drug penetration more than tenfold and reduced tumor burden to less than 3% of that seen with conventional treatment after one week. - The treatment was completed in approximately 30 minutes, compared to much longer exposure times required by standard intravesical chemotherapy. - The study, published in Nature Nanotechnology, represents a preclinical proof-of-concept requiring further validation before clinical trials can begin.
- A pioneering macrophage cell therapy demonstrated significantly improved outcomes for advanced liver disease patients, with 70% achieving transplant-free survival after four years compared to 40% receiving standard care. - The treatment involves converting patients' immune cells into mature macrophages that break down liver scar tissue, reduce inflammation, and promote healthy liver cell growth when re-injected. - Results from the MATCH clinical trial showed eight deaths and no liver transplants among 26 macrophage-treated patients versus nine deaths and five transplants among 24 standard care patients. - The therapy offers potential as the first alternative treatment for end-stage liver disease, addressing the critical shortage of donor organs for transplantation.
