ACTRN12619000738123Completed未知
Validating MRI tools to measure neuroinflammation in vivo using a typhoid vaccine in healthy adults
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- The University of Auckland
- Enrollment
- 20
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Randomised controlled trial
- Primary Purpose
- Diagnosis
- Masking
- Blinded (masking used)
Eligibility Criteria
- Ages
- 18 Years to 55 Years (—)
- Sex
- All
Inclusion Criteria
- •Participant is willing and able to give informed consent for participation in the study
- •In the investigators' opinion, is able and willing to comply with all study requirements
Exclusion Criteria
- •Any physical or psychiatric illness e.g. rheumatologic/autoimmune diseases, major depressive disorder
- •Current use of any prescribed medication e.g. anti-inflammatory, immunomodulatory medications
- •Recreation drug use in the previous six months
- •Contraindications for a typhoid vaccine (known systemic hypersensitivity reaction to any component of TYPHIM Vi or a life-threatening reaction after previous administration of the vaccine or vaccine containing the same substance)
- •Receiving a typhoid vaccine within the past three years
- •Receiving any other vaccines within one month
- •Body-weight <50kg or >120kg.
- •Inability to speak or read English
- •Contraindications for MRI scanning
- •Elevated body temperature (>38.0°C) and/or peripheral signs of acute infection/illness (e.g. sneezing, rhinorrhoea) on the day of the study – can be rescheduled/rescreened at a later date
- •Any other condition judged by the study team as likely to impact on the ability of the participant to complete the study
Investigators
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