Effects of Estrogen on Muscle Gain During 12-weeks of Exercise in Post-menopausal Women
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Muscle mass
研究概览
简要总结
As females age and transition through menopause, the decline in oestrogen level profoundly affects skeletal muscle mass and function. HER-MUSCLE aims to unravel the differences in pre and post menopausal women, in regards to muscle size, strength and function.
Focusing on postmenopausal females, an increasingly at-risk demographic, HER-MUSCLE addresses a critical gap in understanding how oestrogen influences muscle mass and function.
The project involves:
- Molecular Analysis: Advanced techniques will study the muscle microenvironment, focusing on muscle stem cells (MuSCs), fibro-adipogenic progenitors (FAPs), and other cells critical for muscle regeneration and maintenance.
- Mitochondrial Function assessed in vivo via magnetic resonance spectroscopy: The impact of oestrogen on mitochondrial health will be examined, exploring how it preserves mitochondrial function and ability to recovery and resist fatigue in response to muscle contractions.
Our preliminary data indicate that oestrogen can promote muscle protein synthesis. HER-MUSCLE aims to pave the way for novel therapeutic strategies to manage sarcopenia in postmenopausal women, ultimately leading to better health outcomes and enhanced well-being for this growing population segment.
详细描述
As females age and transition through menopause, the decline in oestrogen level profoundly affects skeletal muscle mass and function. HER-MUSCLE aims to unravel the differences in pre and post menopausal women, in regards to muscle size, strength and function.
Focusing on postmenopausal females, an increasingly at-risk demographic, HER-MUSCLE addresses a critical gap in understanding how oestrogen influences muscle mass and function.
The project involves:
- Molecular Analysis: Advanced techniques will study the muscle microenvironment, focusing on muscle stem cells (MuSCs), fibro-adipogenic progenitors (FAPs), and other cells critical for muscle regeneration and maintenance.
- Mitochondrial Function assessed in vivo via magnetic resonance spectroscopy: The impact of oestrogen on mitochondrial health will be examined, exploring how it preserves mitochondrial function and ability to recovery and resist fatigue in response to muscle contractions.
Our preliminary data indicate that oestrogen can promote muscle protein synthesis. HER-MUSCLE aims to pave the way for novel therapeutic strategies to manage sarcopenia in postmenopausal women, ultimately leading to better health outcomes and enhanced well-being for this growing population segment.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 47 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Regular menstrual bleeding (21-35 days cycle).
- •At least 9 menstrual cycles the last year
- •Age >47 years old
- •BMI 20-30
排除标准
- •Only premenopausal women: Follicular stimulating hormone > 30 mmol/L
- •Systematic strength training during the last year (> 1 strength training session per week)
- •Systematic high intensity cardiovascular training during the last year (<2 times per week)
- •Injuries to the legs which may prevent participation in the physical training program
- •Magnetizable metals or electrical devices implanted in the body, such as a pacemaker
- •Use of medication that can influence the effect of immobilization and/or training
- •Muscular or joint disorders which may affect the results
- •Metabolic diseases (such as diabetes and cardiovascular diseases)
- •Previous or present liver or cancer disease
- •Current or previous thrombosis
- •Porphyria
- •Epilepsia
- •Systemic autoimmune disease
- •Smoking or use of other nicotine containing products
- •Claustrophobia
- •Addictive behavior, defined as abuse of cannabis, opioids, or other intoxicating substances.
- •Lack of ability to cooperate
- •Blood parameters out of normal range at the health check
- •Blood pressure above 140/90 mmHg
研究组 & 干预措施
Pre menopausal women
Post menopausal women
结局指标
主要结局
Muscle mass
时间窗: 1 week
Magnetic resonance imaging
次要结局
- Satelitte cells(1 weeks)
- Muscle fiber cross-sectional Area(1 weeks)
- Expression of Muscle proteins(1 weeks)
- FACS Analysis(1 weeks)
- Mitochondria Function in vivo measured as phosphocreatine recovery rate(1 weeks)
- Mitochondria Function in vitro measured as maximal oxygen consumption(1 weeks)
- Body composition(1 weeks)
- Muscle Strength(1 weeks)
- Functional tests(1 weeks)
- Cardiovascular fitness(1 week)
- Maximal fat oxidation rate(1 week)
- Resisting metabolic rate(1 week)
- Questionaires(1 week)
- Physical Activity Level(1 week)
- Flexibility(1 week)
- Knee laxity(1 week)
- Protein expression in adipose tissue(1 week)
- Blood pressure(1 week)
- Blood volume(1 week)
研究者
Mette Hansen
Professor
University of Aarhus