Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Appetitive Behavior
- Sponsor
- Brigham and Women's Hospital
- Enrollment
- 150
- Locations
- 2
- Primary Endpoint
- Change in BOLD response in the ventral striatum
- Status
- Recruiting
- Last Updated
- 4 months ago
Overview
Brief Summary
This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals.
TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.
Detailed Description
The purpose of this study is to conduct a circuit manipulation experiment to test the hypothesis that targeting the cerebellum can alter activity in response to food cues to advance the understanding of the involvement of the cerebellar-striatal circuit in feeding behavior. Participants will undergo an initial screening session to complete informed consent and undergo baseline assessments including physical activity and food craving. Participants will additionally undergo an MRI scan that includes structural and resting-state functional magnetic resonance imaging (rsfMRI). These rsfMRI imagines will be used to isolate individual resting state networks for targeting of rTMS modulation. Participants will then complete two separate testing sessions involving MRI imaging and food intake assessments before and after rTMS. One visit will involve consumption of a filling meal; the other visit will be completed following an overnight fast.
Investigators
Laura M Holsen
Associate Professor of Psychiatry
Brigham and Women's Hospital
Eligibility Criteria
Inclusion Criteria
- •Healthy individuals aged 18 to 65
- •BMI of 20-35.0 kg/m2
- •Normal or corrected-to-normal vision
- •Good general health
- •Ability to understand and willingness to sign written informed consent document
Exclusion Criteria
- •Current and/or past medical conditions
- •Current and/or past eating disorder
- •On a restricted diet and/or taking weight loss medication(s)
- •History of bariatric surgery
- •Weight fluctuation \>3% in past 3 months
- •Recent history of illicit recreational drug abuse
- •Current nicotine use
- •Intellectual disability
- •Conditions that might result in increased risks of side effects or complications from TMS or MRI
Outcomes
Primary Outcomes
Change in BOLD response in the ventral striatum
Time Frame: 30 minutes pre-TMS and 30 minutes post-TMS, at each of two main study visits (fed, fasted)
Change in functional activation of the ventral striatum will be assessed before (pre-TMS) and after (post-rTMS) rTMS stimulation, measured separately at the fed visit and at the fasted visit.
Change in BOLD response in the cerebellum
Time Frame: 30 minutes pre-TMS and 30 minutes post-TMS, at each of two main study visits (fed, fasted)
Change in functional activation of the cerebellum will be assessed before (pre-TMS) and after (post-rTMS) rTMS stimulation, measured separately at the fed visit and at the fasted visit.
Ad libitum snack food intake
Time Frame: baseline, up to 60 minutes post-TMS at each of two main study visits (fed, fasted)
Change in total caloric intake during the ad libitum snack food session will be assessed at the baseline visit and after (post-rTMS) rTMS stimulation, the latter measured separately at the fed visit and at the fasted visit.
Change in food reward valuation
Time Frame: up to 60 minutes pre-TMS and up to 60 minutes post-TMS, at each of two main study visits (fed, fasted)
Change in food reward valuation of high-calorie foods will be assessed using the Willingness to Pay task, measured before (pre-TMS) and after (post-rTMS) rTMS stimulation, measured separately at the fed visit and at the fasted visit.