Cerebellar Transcranial Magnetic Stimulation for Motor Control in Progressive Supranuclear Palsy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Palsy Supranuclear
- Sponsor
- Oregon Health and Science University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- objective posturography
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP. We will use functional near infrared spectroscopy (fNIRS) to examine changes in motor and premotor cortical activity after cerebellar rTMS.
Investigators
Marian L Dale, MD
Associate Professor of Neurology, School of Medicine; Director, OHSU CurePSP Center of Care
Oregon Health and Science University
Eligibility Criteria
Inclusion Criteria
- •probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)
- •age 40-85 at time of screening
- •ability to understand and cooperate with simple instructions in English
- •ability to read at 6th grade reading level in English
- •ability to stand unassisted for at least 30 seconds and to be able walk independently with a walker
- •ability to refrain from new physical and speech therapy programs for the duration of the study
- •ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative or NMDA receptor antagonists for the duration of the study
- •females of child-bearing age must perform a urine pregnancy test and be on reliable birth control during the course of the study
Exclusion Criteria
- •other significant neurological or vestibular disorders
- •presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body
Outcomes
Primary Outcomes
objective posturography
Time Frame: assessed on 4 days during the 8 week study period
The primary endpoint is center of pressure shifts with tilt and with translation, and body sway in quiet stance.
Secondary Outcomes
- fNIRS(assessed on 4 days during the 8 week study period)
- speech analysis(assessed on 4 days during the 8 week study period)