NCT01231646已完成不适用
Does Valproate Increase Levels of Folate Receptor Autoantibodies in Women?
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Levels of Folate Receptor Autoantibodies
研究概览
简要总结
Women who take folate (folic acid) before getting pregnant can lower the risk of giving birth to infant with certain birth defects. However, some medications may affect the action of folate. The purpose of this study is to compare the effect of two anti-epileptic drugs on how folate works in our body.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women ages 18-50 years inclusive who are taking valproate or lamotrigine for neurologic or psychiatric conditions
- •Valproate of lamotrigine must be used as monotherapy at stable doses for 6 weeks prior to the study for the neurologic or psychiatric illness; medications taken for other reasons are not excluded.
排除标准
- •Women with prior exposure to valproate or lamotrigine if they are taking lamotrigine or valproate respectively.
结局指标
主要结局
Levels of Folate Receptor Autoantibodies
时间窗: On the same day after informed consent was obtained
ELISA assays using immobilized folate receptor protein were performed to determine the titers of immunoglobulin G, immunoglobulin M, and combined immunoglobulin G and immunoglobulin M to folate receptor in serum samples collected from both groups of women.
次要结局
未报告次要终点
研究者
研究点 (1)
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