Indonesia Frailty, Aging, and Longitudinal Study
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Change from baseline in frailty status at 1 year
研究概览
简要总结
Frailty is a dynamic process from fit (robust) and pre-frail elderly. There is no previous study that determine the risk factors from fit to pre-frailty and pre-frailty to frailty in Indonesian elderly.
This study was aimed to define the risk factors and clinical outcomes of frailty transitional status in Indonesian elderly.
详细描述
Frailty is an age-associated, biological syndrome characterized by decreased biological reserves, due to dysregulation of several physiological systems, which puts an individual at risk when facing minor stressors, and is associated with poor outcomes (ie, disability, death, and hospitalization).
Frailty identifies a high-risk subgroup and offers characteristics of great clinical importance: a higher reversibility at early stages than disability, and a higher predictive value than chronic disease for adverse outcomes at older ages. It is also the most common condition leading to death in community-dwelling older people.
However, there is current consensus that physical frailty is potentially reversible. It is hence useful to objectively detect frailty among frail elderly persons, as frailty indices serve a useful purpose for risk stratification, predicting need for institutional care and planning of services needed.
To date, there is no study or information about frailty status in Indonesia elderly. This study was aimed to define the risk factors and clinical outcomes of frailty transitional status in Indonesian elderly.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elderly aged >= 60 years old
- •Fit (robust) or pre-frailty;
- •Capable to understand and carry-out the instruction.
排除标准
- •Unwilling to join the study;
- •Abbreviated Mental Test (AMT) score < 8;
- •Geriatric Depression Scale (GDS) score >= 10;
- •Body mass index (BMI) <18,5 Kg/m2;
- •Malnutrition (according to Mini Nutritional Assessment/MNA);
- •Liver cirrhosis, severe liver dysfunction, or serum ALT levels >3 times upper normal limit;
- •Acute illness during inclusion period, eg. pneumonia, pain due to acute arthritis (visual analog scale >6/10), stroke attack, crisis hypertension;
- •Severe cardiac dysfunction: acute decompensated heart failure and/or chronic heart failure functional class III or IV (New York Heart Association classification);
- •Severe pulmonary dysfunction: acute exacerbation of chronic obstructive lung disease stage III or IV (GOLD classification), and/or PaO2 levels < 60 mmHg.
结局指标
主要结局
Change from baseline in frailty status at 1 year
时间窗: Baseline and at 1 year
Frailty status is divided into Fit (robust), Pre-frail, and Frailty.
次要结局
- Change from baseline in mortality at 1 year(Baseline and at 1 year)
- Change from baseline in health-related quality of life at 1 year(Baseline and at 1 year)
- Change from baseline in fall incidence at 1 year(Baseline and at 1 year)
- Change from baseline in hospitality at 1 year(Baseline and at 1 year)
研究者
Siti Setiati
Indonesia Frailty, Aging, and Quality of Life
Indonesia University