The impact of milk protein glycation on muscle protein synthesis after resistance training in healthy young me
- Conditions
- Spieropbouw na inspanningbuilding muscle proteinMuscle protein synthesis
- Registration Number
- NL-OMON49398
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 53
- Males
- Aged between 18-35 years
- Healthy, recreationally active (participating in recreational sports
activities * 1 and * 6 h per week, with a maximum of 2 h resistance-type
exercise)
- 18.5 * BMI * 30 kg/m2
- No physical limitations (i.e. able to perform all activities associated with
daily living in an independent manner).
- Smoking
- Lactose intolerant or allergies to milk proteins
- Regular consumption of protein supplements (e.g. protein powders)
- Musculoskeletal disorders
- Metabolic disorders
- Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories, or prescribed acne
medications).
- Chronic use of gastric acid suppressing medication or anti-coagulants
- Recent (<9 months) participation in amino acid tracer
(L-[ring-13C6]-phenylalanine and L-[3,5-2H2]-tyrosine) studies
- Unstable weight over the last three months
- Diagnosed GI tract disorders or diseases
- Blood donation in the past 2 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary endpoint will be mixed muscle protein synthesis rates over the full<br /><br>assessment period (6h h), as determined using contemporary stable isotope<br /><br>tracer methodology combined with multiple muscle and blood samples. </p><br>
- Secondary Outcome Measures
Name Time Method <p>To compare the impact of low versus high protein glycation on peak plasma<br /><br>lysine concentration, overall plasma amino acid responses, plasma insulin-, and<br /><br>glucose responses. </p><br>