The impact of milk protein glycation on protein digestion and absorption in healthy young me
- Conditions
- Digestie en absorptieDigestion & absorptionProtein breakdown & availability
- Registration Number
- NL-OMON52897
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 17
- Males
- Aged between 18-35 years
- Healthy, recreationally active (participating in recreational sports
activities >= 1 and <= 6 h per week, with a maximum of 2 h resistance-type
exercise)
- 18.5 <= BMI <= 30 kg/m2
- No physical limitations (i.e. able to perform all activities associated with
daily living in an independent manner).
- Smoking
- Lactose intolerant or allergies to milk proteins
- Musculoskeletal disorders
- Metabolic disorders
- Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories, or prescribed acne
medications).
- Chronic use of gastric acid suppressing medication or anti-coagulants
- Unstable weight over the last three months
- Diagnosed GI tract disorders or diseases
- Blood donation in the past 2 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary endpoint will be the appearance of milk protein-derived amino acids<br /><br>in plasma over the full assessment period (6 h), as determined using stable<br /><br>isotope tracer methodology.</p><br>
- Secondary Outcome Measures
Name Time Method <p>To compare the impact of low versus high protein glycation on whole-body<br /><br>protein kinetics (total rate of appearance, exogenous rate of appearance,<br /><br>endogenous rate of appearance, rate of disappearance), whole-body protein<br /><br>metabolism (synthesis, breakdown, oxidation, net balance), peak plasma lysine<br /><br>concentration, overall plasma amino acid responses, plasma insulin-, and<br /><br>glucose responses. </p><br>