The impact of milk protein glycation on muscle protein synthesis after resistance training in healthy young me

Completed

• Conditions: - Milk protein- Protein digestion- Muscle protein synthesis

• Registration Number: NL-OMON22985
• Lead Sponsor: Maastricht University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

Males
- Aged between 18-35 years
- Healthy, recreationally active (participating in recreational sports activities = 1 and = 6 h per week, with a maximum of 2 h resistance-type exercise)
- 18.5 = BMI = 30 kg/m2
- No physical limitations (i.e. able to perform all activities associated with daily living in an independent manner).

Exclusion Criteria

- Smoking
- Lactose intolerant or allergies to milk proteins
- Regular consumption of protein supplements (e.g. protein powders)
- Musculoskeletal disorders
- Metabolic disorders
- Use of any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications).
- Chronic use of gastric acid suppressing medication or anti-coagulants
- Recent (<9 months) participation in amino acid tracer (L-[ring-13C6]-phenylalanine and L-[3,5-2H2]-tyrosine) studies
- Unstable weight over the last three months
- Diagnosed GI tract disorders or diseases
- Blood donation in the past 2 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Muscle protein synthesis rates from 0-6 h following drink ingestion

Secondary Outcome Measures

Name	Time	Method
- Muscle protein synthesis rates from 0-2 and 2-6h<br>- Plasma lysine concentrations<br>- Plasma amino acid concentrations