Improving Attention in Individuals With Long COVID-19

Not Applicable

Recruiting

• Conditions: Long Covid

• Registration Number: NCT06503874
• Lead Sponsor: Shirley Ryan AbilityLab

Brief Summary

This study is to find out if the Attention Processing Training program is a potential treatment for brain fog symptoms, reported by people with Long-Covid. Also investigating the feasibility of completing this program virtually.

Detailed Description

The goal of this project is to test the feasibility, acceptability and efficacy of an attention training intervention (Attention Process Training; APT-3) as a potential treatment for brain fog symptoms experienced by people with Long-Covid. There already is good empirical evidence to support the idea that the APT-3 treatment is feasible and effective in improving attention in people with acquired brain injuries, but information about its efficacy and acceptability in people with Long-Covid brain fog is lacking.

Study Timeline

• Study Start: 2024-03-22
• Status Verified: 2024-07
• Study First Submitted: 2024-07-09
• Study First Submitted QC: 2024-07-10
• Last Update Submitted: 2024-07-10
• Study First Posted: 2024-07-16
• Last Update Posted: 2024-07-16
• Primary Completion: 2026-03-01
• Study Completion: 2027-03-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Aged 18-65 years.
• A history of confirmed SARS-CoV-2 infection.
• Subjective reports of cognitive symptoms that interfere with everyday activities, starting on or shortly after SARS-CoV-2 infection.
• Continuation or development of Long-Covid brain fog 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation.
• Objective attentional deficits as measured by the Conners CPT-312, and/or the Digit Span subtest (WAIS- III13).
• Able to use a keyboard.
• Able to understand and communicate in English.
• Able to consent independently.

Exclusion Criteria

• Being hospitalized due to COVID-19 diagnosis for more than 3 days.
• Pre-morbid neurological conditions that could potentially affect cognition, such as Parkinson's Disease, Alzheimer's Dementia, acquired brain injury.
• Severe depression.
• Currently enrolled in cognitive training or physical exercise training.
• Receiving chemotherapy or radiation within last 6 months.
• Active substance abuse.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Number of participants who successfully completed at least 80% of the study tasks sessions	2 years	Recording the number of participants who completed at least 80% of the study sessions out of the number of all participants who enrolled in the study.

Secondary Outcome Measures

Name	Time	Method
Change of scores in objective attention tests (i.e, CPT 3), pre- and post -intervention	2 year	The Conners Continuous Performance Test Third Edition™ (Conners CPT 3™)

Trial Locations

Locations (1)

Shirley Ryan AbilityLab; 🇺🇸 Chicago, Illinois, United States