Effect of tooth cleaning procedure on reducing blood sugar level and various blood related bio markers

Not Applicable

Conditions: Health Condition 1: E119- Type 2 diabetes mellitus without complications

Registration Number: CTRI/2018/09/015803

Lead Sponsor: BLESSING EMMANUEL P

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1) Patients with chronic periodontitis will be diagnosed according to the criteria of 1999 American Academy of Periodontology Workshop

2) Patients with clinical attachment loss >= 5mm at more than 30% of the sites.

3)Patients with Bleeding on probing

4) Patients with >=20 functional teeth.

5) Patients were considered to be well controlled Type II diabetic when presenting with fasting blood glucose levels of 126mg/dL, and glycated hemoglobin (6.0 to 6.5%). [According to the criteria of American Diabetes Association 2010]

Exclusion Criteria

1) They suffer from any systemic condition (except Type II Diabetes mellitus) that could affect the progression of periodontal disease (immunological disorders), smokers and former smokers, alcoholics and former alcoholics, obese, pregnant and lactating women and those taking oral contraceptive drugs.

2) There is a presence of an active infection other than periodontitis.

3) There is an intake of antibiotics/ corticosteroids and or non steroidal anti-inflammatory drugs during the previous 4 weeks.

4) They had received professional periodontal treatment during the 6 month period prior to the study.

5) They had used mouth rinses containing antimicrobials in the preceding 2 months.

6) Subjects with periapical pathology, orthodontic appliances and multiple systemic complications of diabetes mellitus, inflammatory bowel disease, psoriasis, RA, Nephritis will also be excluded from the study.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of Non Surgical Periodontal Therapy on the Micronuclei Frequency, Serum Malondialdehyde and Serum High Sensitive C â?? Reactive Protein Levels in Chronic Periodontitis Patients with and Without Well Controlled Type 2 Diabetes MellitusTimepoint: 3 months

Secondary Outcome Measures

Name	Time	Method
Reduction of micronuclei, MDA, and Hs-CRP levels in chronic periodontitis patients with type 2 diabetes mellitus thus reducing the cardiovascular risk for those patients.Timepoint: 3 MONTHS