High dose statins in post-coarctectomy patients.

Recruiting

• Conditions: Atherosclerosis in post-coarctectomy patients.

• Registration Number: NL-OMON22766
• Lead Sponsor: ICI

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

Post-coarctectomy patients.

Exclusion Criteria

1. Incapable of giving informed consent;

2. Hypersensitivity to atorvastatin or any of its help substances;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IMT.

Secondary Outcome Measures

Name	Time	Method
1. The quality of life;<br /><br>2. The concentration of serum lipids;<br /> <br>3. Lipid lowering and time effects on the femoral vascular conduit;<br /><br>4. Liver- and renal function;<br /><br>5. Microcirculation (FMD);<br /><br>6. Hypertension;<br /><br>7. Disproport onate systolic hypertension with exercise (cardiovascular exercise testing);<br /><br>8. Exaggerated rise in systolic pressure in response to exercise (cardiovascular exercise testing);<br /><br>9. Left ventricular hypertrophy (echocardiography);<br /><br>10. Heart failure (echocardiography);<br /><br>11. Cerebrovascular accident;<br /><br>12. Ruptured aortic aneurysm;<br /> <br>13. Aortic volume (MRI);<br /><br>14. LVEDV, LVESV, EF, CO (MRI);<br /><br>15. Pulse wave velocity through the thoracic aorta (MRI);<br /><br>16. Extent of LV fibrosis (%) (MRI);<br /><br>17. The number of deaths.