Iron Metabolism in Response to Infectio

• Conditions: A41; Other sepsis

• Registration Number: DRKS00023301
• Lead Sponsor: niversitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-11-17
• Study Completion: 2022-02-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients: Consent by the legal representative, age = 18 years, diagnosis sepsis according to sepsis 3 definition (sepsis-associated organ dysfunction indicated by a change of the Sequential Organ Failure Assessment (SOFA) score by 2 or more points compared to the previous day)
Healthy controls: consent, age = 18 years

Exclusion Criteria

Pregnancy, inclusion in an interventional study, infectious viral diseases (HBV, HCV, HIV, COVID-19) or unknown COVID-19 status, iatrogenic immunosuppression, diagnosis of sepsis > 24h

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
sing molecular biological and immunological methods, parameters of the iron metabolism on cellular and humoral level as well as the function of the immune cells are examined on each of the daily blood samples

Secondary Outcome Measures

Name	Time	Method
Inflammatory markers, occurrence of secondary infections, 30-day survival, length of stay in intensive care, basic demographic, therapeutic and clinical data