The effects of different interventions on perioperative neurocognitive disorders in elderly patients with type 2 diabetes mellitus
Phase 1
- Conditions
- perioperative neurocognitive disorders
- Registration Number
- ChiCTR2400089071
- Lead Sponsor
- Haikou People's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Patients who underwent laparoscopic surgery under elective general anesthesia in Haikou People's Hospital;<br>2. Diagnosed with type 2 diabetes mellitus;<br>3. Aged =60 years, no gender limit;<br>4. ASA grade I to III; <br>5. 18 kg/m^2<= body mass index (BMI) <=30kg/m^2; <br>6. Written informed consent signed by the person or legal representative; <br>7. Able to understand the research process and scale content, and able to communicate effectively with researchers.
Exclusion Criteria
- Severe cardiopulmonary insufficiency; <br>2. Severe hepatic and renal dysfunction;<br>3. Long-term use of sedative and analgesic drugs;<br>4. Pre-operative presence of severe neuropsychiatric disorders;<br>5. Preoperative users of antiepileptic drugs and antipsychotics;<br>6. Hypersensitivity to dexmedetomidine and ropivacaine and contraindications to their use;<br>7 .Persons with visual and hearing impairments that prevent them from communicating;<br>8. Those who are unwilling to cooperate for subjective or objective reasons;<br>9. Preoperative MMSE score for those with cognitive dysfunction (illiteracy =17 points, elementary school education =20 points, middle school education and above =24 points);<br>10. Abnormal coagulation function (PT (prothrombin time) >ULN+3s and/or APTT (activated partial thrombin time) >ULN+10s).
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method mini-mental state examination;S100 calcium-binding protein ß;neurofilament light chain protein;miR-532-5p;
- Secondary Outcome Measures
Name Time Method VAS score;Athens Insomnia Scale, AIS;