Train the sedentary brain: move smart to reduce the risk of dementia. Sub study: Alternating aerobic and strength exercise in APOEe4 carriers and non-carriers in early stage dementia: effects and dose-response relation.
- Conditions
- Dementia, Alzheimer's Disesae, cognitive impairment, apolipoprotein E4, exercise, physical activity - dementie, ziekte van Alzheimer, cognitieve achteruitgang, apolipoproteine E4, fysieke activiteit, beweging
- Registration Number
- NL-OMON26925
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 128
Inclusion Criteria
Age ¡Ý 65 years; diagnosis of dementia; visiting daycare at least three times a week; able to perform the Timed Up & Go Test with or without assistive device, and a Mini Mental State Examination score higher than 20.
Exclusion Criteria
Wheelchair bound, severe cardiovascular problems that limit physical activity, brain trauma, epilepsy, progressive or terminal disease, severe depression, history of alcoholism, severe visual problems, severe auditory problems, problems with the Dutch language and mental incompetence.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive functioning: verbal and visual-spatial memory, working memory, executive functioning (set-shifting, response inhibition), attention and psychomotor speed.
- Secondary Outcome Measures
Name Time Method Physical fitness measured with performance-based tests, level of physical activity, ADLs, mood and quality of life