Mitochondrial Remodeling After Exercise

Not Applicable

Completed

• Conditions: Insulin Resistance; Sedentary Lifestyle; Overweight and Obesity; Metabolic Disease; Mitochondrial Metabolism
• Interventions: Behavioral: Short-term Exercise Training

• Registration Number: NCT04103424
• Lead Sponsor: Oregon State University

Brief Summary

Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-08-23
• Study First Submitted: 2019-08-23
• Study First Submitted QC: 2019-09-23
• Study First Posted: 2019-09-25
• Primary Completion: 2020-11-25
• Study Completion: 2022-12-03
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-12
• Last Update Posted: 2024-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• Age 18-45 years
• Body mass index (BMI) 18-45 kg/m2
• Sedentary (<1 hour of planned exercise per week)

Exclusion Criteria

• Regular exercise (>1 hour of planned exercise per week)
• Smoking, tobacco or nicotine use within the last 1-year
• Fasting glucose >126mg/dL
• Hypertension (systolic pressure >140 mmHg or diastolic pressure >90 mmHg)
• Chronic metabolic or cardiovascular health conditions
• Pregnant, nursing, irregular menses or post-menopausal
• Lidocaine allergy
• Certain medications
• Physical limitations that prevent safe or successful exercise completion
• Diminished capacity for consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Post-training Metabolic Study Visit	Short-term Exercise Training	Participants will complete a second, identical metabolic study visit following 2-weeks of exercise training.

Primary Outcome Measures

Name	Time	Method
Change in skeletal muscle mitochondrial protein degradation peptide products	After 2-weeks of exercise training compared with before training.	Skeletal muscle mitochondrial protein degradation peptide products after 2-weeks of exercise training compared with before training.

Trial Locations

Locations (1)

Oregon State University; 🇺🇸 Corvallis, Oregon, United States