The effect of L-citrulline on human cognitive function: a randomized, double-blind, parallel-group comparative study.
Not Applicable
Recruiting
- Conditions
- Healthy volunteers
- Registration Number
- JPRN-UMIN000012887
- Lead Sponsor
- C'est la vie Shinbashi Clinic, Medical Corporation Shinkokai
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
Not provided
Exclusion Criteria
1) regular medication for circulation system and central nerves system 2) history of psychiatric disorders or cerebrovascular diseases 3) serious liver, kidney, heart, respiratory, endocrine, or metabolic diseases 4) marked abnormal findings for blood and urine tests 5) smoker 6) heavy drinker of alcohol 7) obesity (BMI >= 30)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) The changes in the oxy-Hb concentration and amplitudes and latencies of P300 of event-related potentials 2) Performance of the tasks 3) Psychological tests by using the visual analog scale (VAS)
- Secondary Outcome Measures
Name Time Method 1) vital signs (blood pressure and heart rate) 2) blood test (white blood cell count, red blood cell count, hemoglobin, hematocrit, and platelet count) 3) serum chemistry test (serum total protein, albumin, AST, ALT, LDH, gamma-GTP, urea nitrogen (UN), creatinine, uric acid (UA), sodium, chloride, potassium, total cholesterol, LDL cholesterol, HDL cholesterol, and blood glucose) 4) urinalysis (occult blood, urinary protein, urinary glucose, and urobilinogen)