Does substituting isoflurane with propofol during the last hour of intracranial surgery shorten recovery time and reduce PONV?
- Conditions
- Postoperative nausea and vomiting (PONV) and postoperative recovery time.
- Registration Number
- EUCTR2006-003346-42-SE
- Lead Sponsor
- niversity Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
This study will include patients scheduled for elective intracranial surgery, positioned with Mayfield head-rest and with an expected anesthesia time of at least 4 hours. Patients in the age of 18-75 with ASA physical status ?-?? will be included in the study. Approval by the local ethics committee and written informed consent will be obtained from each patient. The patients will be under betamethason treatment, due to the intracranial process. The number of patients that this study will include is 80.
The patients will be randomly assigned to one of two groups: Group C, (Control) will receive inhalation anesthesia with isoflurane during the whole procedure. Group P (Propofol) will receive isoflurane until the surgeon starts to close the dura, then the isoflurane will be discontinued and propofol infusion will be used instead during the remainder of surgery.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
Criteria of exclusion will be severe cardiac infarction or if the condition of the patient demands another type of anesthesia than that described above.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method