The Impact of Obesity on Nonsurgical Periodontal Therapy
Not Applicable
- Conditions
- PeriodontitisPeriodontal DiseasesObesity
- Interventions
- Registration Number
- NCT01405365
- Lead Sponsor
- Federal University of Rio Grande do Sul
- Brief Summary
The purpose of this study is to investigate the effect that obesity may have on the nonsurgical treatment (with and without the adjunct use of metronidazole) of destructive periodontal diseases (chronic periodontitis).
- Detailed Description
Normal weight (BMI 18.5-24.9 kg/m2) and obese (BMI \>30 kg/m2) women will be randomly assigned to two nonsurgical periodontal treatments:
1. scaling and root planing + placebo
2. scaling and root planing + metronidazole
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 96
Inclusion Criteria
- Normal weight or obese (according to BMI)
- nonsmokers or former smokers (3 or more years)
- no systemic diseases that may affect periodontal treatment (diabetes, osteoporosis, steroid use)
- have 10 teeth present
- have at least 2 teeth with probing depth 6+mm and attachment loss 4+mm
Exclusion Criteria
- Pregnancy
- Development of diabetes or other conditions that may impair periodontal healing
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Metronidazole Metronidazole - Metronidazole Scaling and root planning - Placebo Placebo - Placebo Scaling and root planning -
- Primary Outcome Measures
Name Time Method Probing depth 12 months Defined as the distance from the free gingival margin to the bottom of the pocket/sulcus.
- Secondary Outcome Measures
Name Time Method Attachment level 12 months Defined as the distance from the CEJ to the bottom of the pocket/sulcus.
Trial Locations
- Locations (1)
Universidade Federal do Rio Grande do Sul
🇧🇷Porto Alegre, RS, Brazil