Comparison of Dexmedetomidine and Clonidine as an adjuvant to Bupivacaine 0.25% in supraclavicular brachial plexus block under ultrasound guidance : A prospective randomised double blind study Â
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To study duration of analgesia and time to request of rescue analgesia in first 24hours post surgery
研究概览
简要总结
.Regional anesthesia is the most used procedure for upper limb surgeries.
•Ultrasound guided supraclavicular approach for the brachial plexus block is preferred, as they produce ideal operating conditions with fewer complications
•Apart from local anesthetic agents, multiple other drugs were used as adjuvants.
•In the recent past, both dexmedetomidine and clonidine were extensively studied as an adjuvant agent.
•Alpha 2A receptor specificity of dexmedetomidine over clonidine was quoted to be one of the reasons for better efficacy over clonidine.
•In this study, we will compare dexmedetomidine with clonidine as an adjuvant in upper limb surgeries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA physical status I and II patients of either sex Aged between 18 to 65 years and normal BMI Elective upper limb orthopaedic surgeries.
排除标准
- •Patients with severe medical comorbidities and local site infection Patients receiving adrenoceptor agonist or antagonist therapy.
结局指标
主要结局
To study duration of analgesia and time to request of rescue analgesia in first 24hours post surgery
时间窗: first 30 minutes post surgery and then every 2nd hourly till patient requests for rescue analgesia
次要结局
- Time Of Onset And Duration Of Sensory And Motor Blockade and Any other Side Effects