A Clinical Trial to Study The Effect Of Dexmedetomidine and Clonidine as an adjuvant to Bupivacaine 0.25% in supraclavicular brachial plexus block under ultrasound guidance

Phase 3

Not yet recruiting

• Conditions: Medical and Surgical, (2) ICD-10 Condition: O||Medical and Surgical, (3) ICD-10 Condition: O||Medical and Surgical, (4) ICD-10 Condition: V871||Person injured in collision between other motor vehicle and two- or three-wheeled motor vehicle (traffic), (5) ICD-10 Condition: S529||Unspecified fracture of forearm,

• Registration Number: CTRI/2022/03/041349
• Lead Sponsor: sanjay gandhi institute of trauma and orthopaedics

Brief Summary

.Regional anesthesia is the most used procedure for upper limb surgeries.

•Ultrasound guided  supraclavicular approach for the brachial plexus block is preferred, as they produce ideal  operating conditions with fewer complications

•Apart from local anesthetic agents, multiple  other drugs were used as adjuvants.

•In the recent past, both dexmedetomidine and clonidine were extensively studied as an adjuvant agent.

•Alpha 2A receptor specificity of dexmedetomidine over clonidine was quoted to be  one of the reasons for better efficacy over clonidine.

•In this study, we will compare dexmedetomidine with clonidine as an adjuvant in upper limb surgeries.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-03-23
• Study Start: 2022-04-15

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA physical status I and II patients of either sex Aged between 18 to 65 years and normal BMI Elective upper limb orthopaedic surgeries.

Exclusion Criteria

Patients with severe medical comorbidities and local site infection Patients receiving adrenoceptor agonist or antagonist therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study duration of analgesia and time to request of rescue analgesia in first 24hours post surgery	first 30 minutes post surgery and then every 2nd hourly till patient requests for rescue analgesia

Secondary Outcome Measures

Name	Time	Method
Time Of Onset And Duration Of Sensory And Motor Blockade and Any other Side Effects

Trial Locations

Locations (1)

sanjay gandhi institute of trauma and orthopedics; 🇮🇳 Bangalore, KARNATAKA, India

sanjay gandhi institute of trauma and orthopedics

🇮🇳Bangalore, KARNATAKA, India

Yathish N

Principal investigator

9964277476

YATHISH_HONKAN@YAHOO.COM