The role of RBP4 in human lipid and glucose metabolism
- Conditions
- glucose intoleranceInsulin resistance10018424
- Registration Number
- NL-OMON33098
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Lean subjects:
BMI 20-25 kg/m2 (stable weight)
Age between 20 and 60 years
Obese subjects:
- BMI > 30 kg/m2 for part one or > 35 kg/m2 for part two
- Age between 20 and 60 years
- HOMA-IR > 1.95 for part one
Exclusion Criteria
Lean subjects:
any medical condition (except for gallstone formation) or use of medication
family history of diabetes mellitus type 2
performance of vigorous exercise
Obese subjects:
primary lipid disorder or secondary lipid disorder treated with fibrates
diabetes mellitus type 2 (DM2) treated with thiazolidinediones, DPP4-inhibitors or GLP1-analogues
any medical condition except for glucose intolerance, DM2, hypertension and secondary dyslipidemia
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Expression of RBP4 in liver, skeletal muscle and adipose tissue<br /><br>Glucose production, glucose uptake and lipolysis<br /><br>RBP-4 concentration in plasma</p><br>
- Secondary Outcome Measures
Name Time Method <p>Correlation tissue levels of RBP4 and phosphorylation of insulin signaling<br /><br>proteins</p><br>