The role of RBP4 in human glucose metabolism

Withdrawn

• Conditions: glucose intolerance; Insulin resistance; 10018424

• Registration Number: NL-OMON39627
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Female; BMI > 35 kg/m2; Age between 26 and 50 years; Established T2DM

Exclusion Criteria

Primary lipid disorder or secondary lipid disorder treated with fibrates; T2DM treated with thiazolidinediones, DPP4-inhibitors or GLP1-analogues; Any medical condition except for glucose intolerance, hypertension and secondary dyslipidemia; Bleeding disorder; Untreated primary hypothyroidism; Contra-indications for MR scanning

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Circulating and tissue levels of RBP4, in relation to: endogenous glucose<br /><br>production; hepatic, peripheral and adipose tissue insulin sensitivity; hepatic<br /><br>triglyceride content</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlation levels of RBP4 with hepatic enzymes involved in gluconeogenesis </p><br>