The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment
Completed
- Conditions
- 10012272Vascular Cognitive Impairment / Cognitive complaints by problems in the supply of blood to the brain
- Registration Number
- NL-OMON47838
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Patients with vasculair cognitive impairment, age: 50-80yr, cognitive
complaints, independency in daily life, clinical dementia rating <= 0 / 0,5;
MMSE >22, presence of a primary caregiver
Exclusion Criteria
Diagnosis of dementia; contra-indication for MRI; major neurological /
psychiatric / cardiac or other medical disease that affects cognition and
mobility
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Change in cerebral perfusion, measured with arterial spin labeling (ASL) - MRI</p><br>
- Secondary Outcome Measures
Name Time Method <p>Change in cognitive functions on neuropsychological testing;<br /><br>Change in cardiac function and structure (measured with parameters on cardiac<br /><br>MRI);<br /><br>Change in brain structure (measured with parameters on brain MRI);<br /><br>Change in physical fitness;<br /><br>Change in blood biomarkers;<br /><br>Change in neuropsychiatric measures and quality of life;<br /><br>Change in cerebral autoregulation and cerebral vasomotor reactivity; </p><br>