*EffeCt of lung ultrasOuNd-guided Fluid deresuscItation on Duration of vEntilation iN intensive Care unit patiEnts (CONFIDENCE-trial)*

Recruiting

• Conditions: respiratory failure; mechanical ventilation

• Registration Number: NL-OMON54414
• Lead Sponsor: Amsterdam UMC

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 1000

Inclusion Criteria

- admitted to one of the participating ICUs; and
- expected to be under invasive ventilation for longer than 24 hours

Exclusion Criteria

(a) age < 18 years;
(b) pregnancy;
(c) participation in other interventional trials with similar endpoints;
(d) conditions in which LUS cannot be performed or correctly interpreted, i.e.,
chest abnormalities, morbid obesity, and pre-existing interstitial lung
disease,
(e) previous participation in this RCT
(f) patients transferred from another center and invasively ventilated for
longer than than 24 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Number of ventilator-free days and alive at day 28 (*VFD-28*)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>ICU- and hospital length of stay; ICU-, hospital- and 90-day mortality;<br /><br>cumulative fluid balance at successive days; proportion of patients who develop<br /><br>kidney injury or atrial fibrillation.</p><br>