Assessing How Normal Variations in CT Scanning Affects Its Interpretation
Active, not recruiting
- Conditions
- Colorectal Cancer Metastatic
- Interventions
- Diagnostic Test: CT scan
- Registration Number
- NCT03038568
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Brief Summary
The purpose of the study is to see how measurements of tumor differences vary with slight changes in CT scan parameters. Reproducible radiomic features can be extracted for abdominal tumors, and specifically colorectal liver metastases, imaged with clinical CT scanners even in the setting of variable scan parameters and variable contrast timing. Participants will be consented to undergo an additional CT of their abdomen.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 169
Inclusion Criteria
- Patients ≥ 18 years of age on the day of signed informed consent
- Patients scheduled and approved for contrast enhanced CT that includes imaging of the abdomen and pelvis following the Department of Radiology standard of care protocol as per local institutional guidelines
- Patients with measurable colorectal liver metastases on prior imaging, with at least one tumor greater than 2.0 cm in axial maximal diameter
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Exclusion Criteria
- Patient who is pregnant and/or lactating
- Patient scheduled for CT that includes the abdomen with a multiphasic contrast enhanced protocol (e.g. Triple Phase or Quadruple Phase Liver CT)
- Patient who require reduced intravenous contrast dose based on the Department of Radiology contrast policy as per local institutional guidelines
- Any other medical condition, including mental illness or substance abuse, deemed by the Investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or follow up procedures
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cohort 8 CT scan - 5 second time gap between routine abdominal CT and add on CT, Noise index 14 Cohort 2 CT scan -15 second time gap between routine abdominal CT and add on CT, Noise Index of 14 Cohort 9 CT scan - 5 second time gap between routine abdominal CT and add on CT, Noise index 16 Cohort 10 CT scan + 5 second time gap between routine abdominal CT and add on CT, Noise index 12 Cohort 1 CT scan -15 second time gap between routine abdominal CT and add on CT, Noise Index of 12 Cohort 3 CT scan -15 second time gap between routine abdominal CT and add on CT, Noise Index of 16 Cohort 4 CT scan -10 second time gap between routine abdominal CT and add on CT, Noise index 12 Cohort 11 CT scan + 5 second time gap between routine abdominal CT and add on CT, Noise index 14 Cohort 7 CT scan - 5 second time gap between routine abdominal CT and add on CT, Noise index 12 Cohort 12 CT scan + 5 second time gap between routine abdominal CT and add on CT, Noise index 16 Cohort 14 CT scan + 10 second time gap between routine abdominal CT and add on CT, Noise index 14 Cohort 5 CT scan -10 second time gap between routine abdominal CT and add on CT, Noise index 14 Cohort 6 CT scan -10 second time gap between routine abdominal CT and add on CT, Noise index 16 Cohort 17 CT scan + 15 second time gap between routine abdominal CT and add on CT, Noise 14 Cohort 18 CT scan + 15 second time gap between routine abdominal CT and add on CT, Noise 16 Cohort 13 CT scan + 10 second time gap between routine abdominal CT and add on CT, Noise index 12 Cohort 15 CT scan + 10 second time gap between routine abdominal CT and add on CT, Noise index 16 Cohort 16 CT scan + 15 second time gap between routine abdominal CT and add on CT, Noise 12
- Primary Outcome Measures
Name Time Method assess the stability (reproducibility) of radiomic measurements obtained from repeat abdominal CT scans 2 years There will be 18 cohorts, each cohort differing by the length of the time gap in acquisition and noise index. In addition each acquisition will be reconstructed in 21 different ways (combinations of 3 slice thicknesses and 7 ASiR levels).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Memorial Sloan Kettering Cancer Center
🇺🇸New York, New York, United States
MD Anderson Cancer Center, Texas (Data collection only)
🇺🇸Houston, Texas, United States