TO COMPARE EFFICACY OF DEXMEDETOMIDINE AND NALBUPHINE FOR TREATMENT OF POSTSPINAL SHIVERING

Not yet recruiting

• Conditions: Patients posted for elective surgery under spinal anaesthesia who develop post spinal shivering

• Registration Number: CTRI/2018/07/014854
• Lead Sponsor: Dr Harpreet kaur

Brief Summary

SUMMARY

**A COMPARATIVE STUDY TO EVALUATE THE EFFICACY OF  INTRAVENOUS DEXMEDETOMIDINE AND NALBUPHINE FOR TREATMENT OF POST SPINAL****SHIVERING**

                          **INTRODUCTION :** Shivering is one of the most common complications of a central neuraxial blockade. In this study we aim to compare the efficacy of intravenous dexmedetomidine and nalbuphine for treatment of post spinal shivering in terms of response time,success rate and recurrence of shivering .Along with this we will also compare haemodynamic and adverse effects of these drugs

**PURPOSE OF STUDY**

The aim of study is  to compare the efficacy  of intravenously administered dexmedetomidine and nalbuphine in treatment of   shivering after  spinal anaesthesia in terms of

1.     Response time ( time of complete disappearance of shivering after treatment ).

2.     Success rate ( if cessation of shivering occur  with in 15 min of treatment).

3.     Recurrence of shivering after success. 4.Haemodynamic effects.5.Adverse effects.

   REFERENCESR1.    Paner M, Murugaiyan P, Rao SV. A comparative study of intravenous dexmedetomidine and intravenous clonidine for post spinal shivering in patients undergoing lower limb orthopaedic surgeries*.* Anesth Essays Res.2017;11:151-4

2.    BajwaSJ,Gupta S, Kaur J, Singh A,ParmarS.Reduction in the incidence of shivering with perioperative dexmedetomidine: A randomised prospective study. J Anaesthesiol Clin Pharmcol.2012;28:86-91.

3.    Mittal G, Gupta K, Katyal S, Kaushal S.Randomised double blind comparative study of dexmedetomidine and tramadol for post spinal shivering. Indian J anaesth.2014;58(3):257-62.

4.    Singh S, Verma V K, Parsad C, Parkash J. Randomized double blind comparative study of dexmedetomidine and tramadol for prevention of post operative shivering in transurethral resection of prostrate under spinal anaesthesia*.* J Evolution. Med. Dent. Sci. 2016;5(13):572-5.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-07-20
• Last Update Posted: 2020-04-29

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

ASA grade I-II Patients during elective surgeries who develop post spinal shivering.

Exclusion Criteria

• 1.Patient’s refusal for surgery under spinal anaesthesia 2.Any Contraindication to regional anaesthesia 3.Known hypersensitivity to dexmedetomidine or nalbuphine 4.ASA grade III and IV 5.Shivering due to allergic reaction to blood / blood products and other drugs administered during surgery.
• 6.Pregnancy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Response time,	every 5 mins for 30 mins and every 15 mins upto 120 mins after spinal
success rate,	every 5 mins for 30 mins and every 15 mins upto 120 mins after spinal
Recurrence of shivering after success	every 5 mins for 30 mins and every 15 mins upto 120 mins after spinal

Secondary Outcome Measures

Name	Time	Method
Haemodynamic parameters,	Adverse Effects

Trial Locations

Locations (1)

GGS Medical college and hospital; 🇮🇳 Faridkot, PUNJAB, India

GGS Medical college and hospital

🇮🇳Faridkot, PUNJAB, India

Dr Harpreet Kaur

Principal investigator

9876323555

harpreetk555.gill@gmail.com