Changes in fetal DNA modification associated with maternal blood sugar during pregnancy

Completed

• Conditions: Maternal-fetal effects of metabolism in pregnancy; Pregnancy and Childbirth

• Registration Number: ISRCTN13534922
• Lead Sponsor: und University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-13
• Last Update Posted: 2 October 2017

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

In total, we will recruit around 30 pregnant women:
1. Aged 25-35 before gestational week 12+6

Half of the recruited women (50%) will have a high risk of gestational diabetes mellitus:
1. Family history of diabetes
2. Prior pregnancy affected by diabetes
3. Current obesity

Half of the recruited women (50%) are expected to have a normal pregnancy not complicated by gestational diabetes mellitus (controls).

If a control woman develops gestational diabetes, she will be invited to continue to take part in the study and be monitored as per standard of care; we will then seek to recruit an additional woman to the control arm to ensure an adequate number of participants in the study.

Exclusion Criteria

1. Not of Scandinavian origin
2. Use of assisted reproductive technology
3. History of three or more first trimester miscarriages
4. Tobacco use (smoking/snus) in the previous three months
5. Diagnosed PCOS
6. History of gastric bypass surgery
7. Type 1 diabetes
8. Non-Swedish speaker
9. Planned termination of pregnancy or planning to give up infant for adoption

Study & Design

• Study Type: Observational
• Study Design: Not specified