Comparison Between Remifentanil Target-controlled Infusion and Dexmedetomidine Bolus Administration for Smooth Emergence From General Sevoflurane Anesthesia

Not Applicable

Completed

• Conditions: Thyroid Neoplasm
• Interventions: Drug: dexmedetomidine; Drug: Normal Saline

• Registration Number: NCT01617694
• Lead Sponsor: Yonsei University

Brief Summary

Remifentanil target-controlled infusion and dexmedetomidine single-dose administration are known to reduce airway response and haemodynamic stimulation during anaesthetic recovery. The investigators will compare the effects of two drugs on prevention of cough during emergence from general sevoflurane anaesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-06
• Primary Completion: 2011-11
• Study Completion: 2011-11
• Status Verified: 2012-06
• Study First Submitted: 2012-06-05
• Study First Submitted QC: 2012-06-11
• Last Update Submitted: 2012-06-11
• Study First Posted: 2012-06-12
• Last Update Posted: 2012-06-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 65

Inclusion Criteria

• female patient,
• aged 20-60 yr,
• ASA physical status 1-2,
• patients undergoing elective thyroidectomy under general anesthesia

Exclusion Criteria

• sighs of difficult airway,
• history of respiratory disease or chronic cough,
• cardiovascular disease,
• pregnant or breast-feeding woman.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group R	Normal Saline	continuation of remifentanil target controlled infusion (TCI) at effect-site concentration of 2 ng/ml during anesthetic recovery until extubation.
group D	Normal Saline	remifentanil TCI discontinuation and dexmedetomidine 0.5 mg/kg intravenous injection before 10 min of the end of surgery
group R	dexmedetomidine	continuation of remifentanil target controlled infusion (TCI) at effect-site concentration of 2 ng/ml during anesthetic recovery until extubation.
group D	dexmedetomidine	remifentanil TCI discontinuation and dexmedetomidine 0.5 mg/kg intravenous injection before 10 min of the end of surgery

Primary Outcome Measures

Name	Time	Method
coughing response	from discontinuation of anesthetic agent (sevoflurane) to 5 min after extubation.	Emergence cough was defined as the cough occurrence during peri-extubation period, from sevoflurane discontinuation to 5 min after extubation. The severity of cough was assessed and recorded by the following cough grading system: Grade 0, no cough; Grade 1, single cough with mild severity; Grade 2, cough persistence less than 5 s with moderate severity; Grade 3, severe, persistent cough for more than 5 s (bucking).

Trial Locations

Locations (1)

Severance hospital; 🇰🇷 Seoul, Korea, Republic of