Is High Sensibility Troponins a Dialysable Marker in Hemodialysis Patients and Does it Have Prognostic Value?

Not Applicable

Completed

• Conditions: Renal Failure
• Interventions: Other: Hs-TNT dosage

• Registration Number: NCT02111733
• Lead Sponsor: Université de Sherbrooke

Brief Summary

Evaluation of High sensibility troponin levels modification by hemodialysis in terminal renal failure patient at Sherbrooke University Hospital Center as determined by serial measurements. Verification of potential effects of these levels and their variation as predictors of cardiovascular outcomes and events at 6 and 12 months.

Detailed Description

Recruiting of hemodialysis patients of the nephrology renal supplementation clinics at Sherbrooke University Hospital Center to measure three blood level of high-sensibility troponins before and after standard dialysis. Verification on the variation of these levels after dialysis. Follow-up at 6 and 12 months of the patient for Cardiovascular events and death and verification of a possible predictive value of troponin blood levels for these events.

Study Timeline

• Study Start: 2013-06
• Primary Completion: 2013-09
• Study Completion: 2013-09
• Study First Submitted: 2013-12-10
• Status Verified: 2014-04
• Study First Submitted QC: 2014-04-08
• Last Update Submitted: 2014-04-08
• Study First Posted: 2014-04-11
• Last Update Posted: 2014-04-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• over 50 years, no symptoms, over 1 months of hemodialysis

Exclusion Criteria

• 1 or more in the last month; Acute coronary syndrome, Heart failure decompensated, Myo or Pericarditis, Pulmonary embolism, Sepsis/shock, Stroke or transient ischemic attack, Malignant high blood pressure, Arrythmia, electrical cardio-version, major trauma, significant burnings (>25%), Chemotherapy, Cardiovascular surgery, percutaneous angio-intervention,
• Chronic systemic disease (sarcoidosis, amyloidosis, LED, Etc.)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Hs-TnT	Hs-TNT dosage	Hs-TNT dosage

Primary Outcome Measures

Name	Time	Method
High sensibility troponins T blood level variation	1 week	Verification of high sensibility troponins T blood after classical hemodialysis compared to pre-treatment levels.

Secondary Outcome Measures

Name	Time	Method
Prognostic value of high sensibility troponins T blood level variation	at 6 and 12 months	Evaluation of a potential prognosis value of high sensibility troponins T blood levels and its variation after hemodialysis.

Trial Locations

Locations (2)

University of Sherbrooke; 🇨🇦 Sherbrooke, Quebec, Canada

Centre hospitalier universitaire de Sherbrooke; 🇨🇦 Sherbrooke, Quebec, Canada