Effect of alpha-lipoic in the control of acute pain and levels of biomarkers in surgery of femur fracture
Not Applicable
- Conditions
- Pain, PostoperativeAnesthesia and AnalgesiaElective Surgical ProceduresFemoral FracturesC26.404.061C23.550.767.700E04.249
- Registration Number
- RBR-95xwz8
- Lead Sponsor
- Instituto Doutor José Frota
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Patients older than 18 years and less than 65 years of age, of both sexes, with physical status ASA I and ASA II according to the American Society of Anesthesiologists (ASA) Anesthetic Care Guidelines, scheduled for elective surgery in femur fracture correction
Exclusion Criteria
Volunteers who were hypersensitive to any of the drugs used in the study, who were pregnant, had kidney disease, coagulation disorder, puncture site infection, clinical signs of hypovolemia, who could not collaborate with the evaluation of postoperative analgesia and users of illicit drugs.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of postoperative analgesia, measured by analog scale of pain and decreased postoperative opioid consumption;Não houve alteração no grau de dor pela escala analógica visual ou no consumo de opioide no pós-operatório
- Secondary Outcome Measures
Name Time Method Expected outcome 1: reduction of lipid peroxidation in the trans and post-operative, by measuring levels of Tbars, nitrite land Glutathione;Found outcome1: reduction of lipid peroxidation in transoperatorio, by the decrease in blood levels of Tbars. Without change in other markers;Expected outcome 2: to increase the satisfaction with the anesthetic technique;Outcome found 2: no difference in satisfaction with the anesthetic technique