Does eating oranges reduce inflammatory and other risk markers related to cardiovascular diseases?

Not Applicable

Completed

• Conditions: Effect of eating oranges on cardiovascular disease biomarkers in healthy people; Circulatory System

• Registration Number: ISRCTN17330010
• Lead Sponsor: niversitat de Valencia

Brief Summary

2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32610451/ (added 04/10/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-08-13
• Study Completion: 2019-12-31
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Healthy men and women

Exclusion Criteria

1. Diseased
2. Allergic to oranges
3. Immunodeficiency or HIV-positive status
4. Liver cirrhosis or chronic renal failure
5. Serious psychiatric disorders: schizophrenia, bipolar disease, eating disorders, depression, etc
6. Any severe co-morbid condition
7. Alcohol abuse or addition
8. History of major organ transplantation
9. Concurrent therapy with immunosuppressive drugs or cytotoxic agents
10. Current treatment with systemic corticosteroids
11. Current use of weight loss medication
12. Patients with an acute infection or inflammation
13. Any other condition that may interfere with the completion of the study protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Classical biochemical parameters related to cardiovascular risk at baseline and 4 h/1 month, also including novel omics markers (in plasma and/or urine) analyzed by metabolomics (also including markers of intake), gene expression and other omics

Secondary Outcome Measures

Name	Time	Method
<br> For the short-term crossover intervention trial, measured at baseline and 4 h:<br> 1. Blood pressure<br> 2. Anthropometric variables (weight, height, waist circumference and body composition by bioimpedance)<br> 3. Genetic polymorphisms<br> 4. Food intake measured by a validated food frequency questionnaire<br> 5. Taste perception tests with standardized tastants for bitter, sour, sweet, umami and salty<br><br> For the 1-month intervention, measured at baseline and 1 month:<br> 1. Blood pressure<br> 2. Anthropometric variables (weight, height, waist circumference and body composition by bioimpedance)<br> 3. Genetic polymorphisms<br>