Home-based High-intensity Interval Training to Improve Colorectal Cancer Survivorship: Feasibility and Relationship With Novel Surrogate Biomarkers of Colorectal Cancer Recurrence
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 4
- 主要终点
- Feasibility of home-based high-intensity interval training among colorectal cancer survivors
研究概览
简要总结
This 12-week, exercise study will assess the feasibility of a home-based high-intensity interval training (HIIT) program among colorectal cancer survivors and explore the impact of home-based HIIT compared to a standard home-based moderate-intensity continuous aerobic exercise program on physical outcomes linked with survival from colorectal cancer and surrogate blood markers of colorectal cancer recurrence.
HIIT is a type of aerobic exercise that includes short bursts (i.e. 1-4 minutes) of vigorous exercise followed by longer periods of moderate to lower intensity exercise (i.e. 1-10 minutes). Participants in this study will be randomly assigned into a personalized home based exercise program - either high-intensity interval training (HIIT) or moderate-intensity continuous aerobic exercise (MICE).
This pilot study will provide us with preliminary evidence for a larger trial aimed to compare the effectiveness of these two different types of home-based exercise programs on physical outcomes linked with survival, quality of life, and surrogate blood markers of colorectal cancer recurrence.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who are no more than five years post resection and/or adjuvant therapy for stage II-III Colorectal cancer (CRC).
- •Age 19-75 years old.
- •Engaging in less than 90 minutes per week of structured moderate- or vigorous-intensity aerobic exercise in the past three months
- •No known cardiovascular, metabolic or renal disease, and no signs/symptoms suggestive of cardiovascular, metabolic, or renal disease.
- •Must be able to read, speak and understand English
- •Willing to complete two assessment sessions (at baseline and 12 weeks).
- •Willing to engage in moderate- or vigorous-intensity aerobic exercise at home and use mobile health technology to track exercise adherence to the exercise prescription.
- •Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines.
- •Have regular access to a smart phone and willing to download a free application for device tracking
排除标准
- •Functional limitations requiring a walker, scooter, or wheelchair.
- •Clinically evident recurrent disease.
- •Resting blood pressure ≥140/90 at the time of baseline testing.
- •No access to smart phone and/or not willing download the device app
结局指标
主要结局
Feasibility of home-based high-intensity interval training among colorectal cancer survivors
时间窗: 12 weeks
Feasibility will be assessed by adherence to the home-based high-intensity interval training protocol, which is defined at the participant level as completing ≥70% of workouts consistent with the exercise prescription. The intervention will be considered feasible if ≥75% of participants meet or exceed the 70% criterion.
次要结局
未报告次要终点
研究者
Adriana Coletta
Assistant Professor
University of Utah