Observational Study of Oxygen Delivery During a Fractional Fluid Expansion

Completed

• Conditions: Hypovolemia; Impaired Oxygen Delivery; Cardiac Output, Low
• Interventions: Drug: hydroxyethylstarch 130/0.4

• Registration Number: NCT01826253
• Lead Sponsor: University Hospital, Caen

Brief Summary

Fluid expansion during cardiocirculatory insufficiency was helped by cardiac output monitoring. However, the goal of fluid expansion was to increase the oxygen delivery, which consider cardiac output, but also Haemoglobin which decrease during a fluid challenge. The maximalization of cardiac output could decrease the oxygen delivery if the haemodilution was too wide. The aim of this study was to describe the oxygen delivery during a fluid expansion conducted for cardiac output maximalization, following actual guidelines.

Detailed Description

One group of 20 anticipated patients

Study Timeline

• Study First Submitted: 2013-03-20
• Study Start: 2013-04
• Study First Submitted QC: 2013-04-03
• Study First Posted: 2013-04-08
• Status Verified: 2013-05
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Last Update Submitted: 2014-06-13
• Last Update Posted: 2014-06-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Adults over 18 years
• Patients in intensive care after cardiac surgery under mechanically ventilation and with oesophageal Doppler

Exclusion Criteria

• Arrythmia
• Pregnancy or childrens
• Patients without cardiac output monitoring with oesophageal Doppler
• Patients without medical indication for fluid expansion
• Urgency surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Hypovolemia	hydroxyethylstarch 130/0.4	Fluid expansion

Primary Outcome Measures

Name	Time	Method
Measurement of oxygen delivery	only during the fluid challenge	Retrospective calculation of oxygen delivery (ml.min.m-2)during a fractional fluid expansion every 100ml of hydroxyethyl starch until cardiac output maximalization with oesophageal Doppler and arterial gazes (for PaO2 and Haemoglobin)from arterial line.

Secondary Outcome Measures

Name	Time	Method
Study of central venous saturation	only during the fluid challenge	Central venous gazes after each mini fluid challenge until cardiac output maximalization, from a central line

Trial Locations

Locations (1)

University Hospital of Caen; 🇫🇷 Caen, France