Puberty in Girls Followed for Cystic Fibrosis
- Conditions
- Cystic Fibrosis
- Registration Number
- NCT02562911
- Lead Sponsor
- University Hospital, Toulouse
- Brief Summary
In the general population, age of puberty, and age of menarche in girls, are closely correlated with those of their mother. The severity of chronic disease has an impact on the stature, the weight gain and the onset of puberty: age of menarche is even later that chronic illness is serious. Cystic fibrosis is one of the major chronic diseases of children.
Neonatal screening is organized since 2002, most girls with cystic fibrosis therefore currently have a very specialized and early care. Older patients were diagnosed during childhood. The optimization of the nutritional and respiratory management has allowed over the past two decades a significant improvement in the survival of these patients. Most young people reach adulthood, puberty and reproductive desire are a crucial issue in the care of these young adults.
In literature, it is often noted an age of menarche delayed an average of 2 years compared to the general population, but correlated with the age of menstruation from the mothers.
The factors involved in the conduct of cycles in the girl followed for cystic fibrosis are poorly known and there are few data on the characteristics of cycles. The menstrual irregularity and amenorrhoea episodes concern nearly half of women.
On the pathophysiological level, studies in animals show that there is a direct effect of CFTR (Cystic Fibrosis Transmembrane Regulator) on the hypothalamic pituitary gonadal and reproductive capacity in mice.
The literature data on the pubertal development, fertility and hormonal profile of these girls are for studies with low numbers and are very old. There is to date no French cohort study on this topic.
The study is a multicenter cross-sectional descriptive study for pubertal and gynecological characteristics in girls followed annually in the reference centers Cystic Fibrosis two inter-region.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 166
- Patient diagnosed with cystic fibrosis
- Girl aged 8 years of age, adolescents and young adults, had period or not,
- visit the Reference and Competence Center of Cystic Fibrosis.
- Affiliated to a social security scheme
- Lack of consent of the legal representative or the relevant patient.
- Patient majoring in legal disability or minor patient whose legal representative is legal disability
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The age of menarche in girls followed for cystic fibrosis in France Day 0
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (7)
CHU Besan莽on St Jacques
馃嚝馃嚪Besancon, France
Canton- H么pitaux de Brabois
馃嚝馃嚪Nancy, France
H么pital des Enfants-Pellegrin
馃嚝馃嚪Bordeaux, France
H么pital d'Enfants
馃嚝馃嚪Dijon, France
H么pital de Hautepierre
馃嚝馃嚪Strasbourg, France
H么pital des enfants Purpan
馃嚝馃嚪Toulouse, France
American Memorial Hospital
馃嚝馃嚪Reims, France