Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency

Not Applicable

• Conditions: Accident Caused by Snow Avalanche
• Interventions: Other: extreme hypercapnia induced by ventilation insufficiency

• Registration Number: NCT04835545
• Lead Sponsor: Czech Technical University in Prague

Brief Summary

The aim of the study is to investigate Work of Breathing of a person in simulated avalanche snow and consequent use of the measured data for judging which one of three simulated scenarios are alike while increasing hypercapnia in the simulated avalanche snow.

Detailed Description

The study is a part of a university diploma thesis aimed at studying physiological conditions and development of breathing parameters of a person breathing in the simulated avalanche snow. The Investigator is measuring Work of Breathing in three scenarios: a) 2L air pocket, b) 2L air pocket with resistance compensation and c) no air pocket. The investigator hypothesize that the Work of Breathing during compensation of air pocket will be alike with no air pocket scenario, thus proving significance of the resistance reduction for survival. The aim of the study is to investigate the effect of Work of Breathing on gas exchange in subjects breathing into the simulated avalanche snow scenarios.

Study Timeline

• Study Start: 2021-03-29
• Study First Submitted: 2021-04-05
• Study First Submitted QC: 2021-04-05
• Study First Posted: 2021-04-08
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-20
• Last Update Posted: 2022-07-22
• Primary Completion: 2024-04-01
• Study Completion: 2024-04-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• healthy and fit volunteers, classified as The American Society of Anesthesiologists class I
• without a smoking history

Exclusion Criteria

• Tiffeneau Index less than 0.70
• any cardiovascular or respiratory condition

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Wet Perlite, no air pocket	extreme hypercapnia induced by ventilation insufficiency	Breathing in the simulated avalanche snow. Breathing into model of wet perlite with no air pocket
Wet Perlite 2L air pocket with resistance compensation	extreme hypercapnia induced by ventilation insufficiency	Breathing in the simulated avalanche snow. Breathing into model of wet perlite 2L air pocket with resistance compensation
Wet Perlite, 2L air pocket	extreme hypercapnia induced by ventilation insufficiency	Breathing in the simulated avalanche snow. Breathing into model of wet perlite with 2L air pocket

Primary Outcome Measures

Name	Time	Method
The length of breathing	Continuously within up to 7 minute interval from the beginning of the breathing experiment	Time to termination of the breathing experiment due to the decision of the tested subject, or determined by high end-tidal carbon dioxide value or by the order by the clinician assessing the health status of the subjects.

Trial Locations

Locations (1)

Czech Technical University, Faculty of Biomedical Engineering; 🇨🇿 Kladno, Czechia