The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing

Not Applicable

• Conditions: Cardiac Output, High; Hypercapnia; Hypoxia
• Interventions: Other: Hypoxic; Other: Hypercapnic; Other: Hypoxic and Hypercapnic

• Registration Number: NCT05441007
• Lead Sponsor: Czech Technical University in Prague

Brief Summary

The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

Detailed Description

Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.

Study Timeline

• Status Verified: 2022-06
• Study First Submitted: 2022-06-25
• Study Start: 2022-06-26
• Study First Submitted QC: 2022-06-29
• Last Update Submitted: 2022-06-29
• Study First Posted: 2022-07-01
• Last Update Posted: 2022-07-01
• Primary Completion: 2023-10-30
• Study Completion: 2024-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Healthy volunteers

Exclusion Criteria

• pregnancy
• severe cardiovascular conditions
• severe asthma or other severe respiratory conditions
• injury to the upper limbs or hands that could affect the peripheral perfusion
• diabetes
• hypotension or hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Hypoxic	Hypoxic	Participants inhale ambient air, the hypoxic gas mixture, and ambient air.
Hypercapnic	Hypercapnic	Participants inhale ambient air, the hypercapnic gas mixture, and ambient air.
Hypoxic and Hypercapnic	Hypoxic and Hypercapnic	Participants inhale ambient air, the hypoxic and hypercapnic gas mixture, and ambient air.

Primary Outcome Measures

Name	Time	Method
Changes in Cardiac output due to the induced hypoxia and hypercapnia	1 hour	Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Cardiac output will change
Changes in Perfusion index due to the induced hypoxia and hypercapnia	1 hour	Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Perfusion index will change

Trial Locations

Locations (1)

Czech Technical University in Prague; 🇨🇿 Kladno, Czechia