Effects of Hypercapnia on Emergence From General Anesthesia Under Propofol

Not Applicable

Completed

• Conditions: Anesthesia Recovery Period; Anesthesia, Intravenous
• Interventions: Procedure: Rebreathing tube; Procedure: No rebreathing tube (Nothing)

• Registration Number: NCT01531491
• Lead Sponsor: DongGuk University

Brief Summary

Hypercapnia derives increase of cerebral blood flow and cardiac output. It means that the rate of propofol elimination from the brain and the blood will be increased and the patient will awake more quickly. There has been no study about the effects of hypercapnia. The investigators will evaluate hypercapnia's effects on the recovery time from propofol anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2012-02-06
• Study First Submitted QC: 2012-02-10
• Study First Posted: 2012-02-13
• Primary Completion: 2013-06
• Study Completion: 2013-06
• Status Verified: 2015-02
• Last Update Submitted: 2015-02-12
• Last Update Posted: 2015-02-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• American Society of Anesthesiologists physical status (ASA PS) I-II
• Age 20 - 60 years male and female
• Elective schedule with minor surgery under general anesthesia

Exclusion Criteria

• Body mass index (BMI) >= 30 (kg/m2)
• Patient with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history
• Patient with medication affecting on this study
• Patient with general anesthesia history within one month

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hypercapnia group	Rebreathing tube	Respiratory rate will be 10/min and the rebreathing tube will be connected between the y-piece of corrugated tube and the tracheal tube to maintain the partial pressure of the end-tidal carbon dioxide at around 50 mmHg during emergence after propofol anesthesia.
Hypocapnia group	No rebreathing tube (Nothing)	No rebreathing tube (Nothing) will be connected. Respiratory rate will be 10/min and the tidal volume will be modulated to maintain the partial pressure of the end-tidal carbon dioxide at around 30 mmHg during emergence after propofol anesthesia.

Primary Outcome Measures

Name	Time	Method
Time to open eyes under investigator's command	From cessation of propofol infusion to patient's eye opening (seconds)	After stopping propofol infusion, every 30 seconds, the investigator (caregiver) will command the patient, "Open your eyes". When the patient opens eyes, the time will be recorded. The patients will be followed for an expected average of 10 minutes.

Secondary Outcome Measures

Name	Time	Method
Time to extubation	From cessation of propofol infusion to extubation (sec)	After stopping propofol infusion, When the patient breaths spontaneously with adequate tidal volume and respiratory rates, the trachea will be extubated and the time will be recorded. The patients will be followed for an expected average of 15 minutes.
Time to breath spontaneously	From cessation of propofol infusion to patient's spontaneous breathing (sec)	The time from cessation of propofol infusion to patient's spontaneous breaths will be recorded. The patients will be followed for an expected average of 10 minutes.
Time to open mouth under investigator's command	From cessation of propofol infusion to patient's mouth opening (seconds)	After the patient opens the eyes, every 10 seconds, the investigator command the patient, "Open your mouth.". When the patient opens mouth, the time will be recorded. The patients will be followed for an expected average of 12 minutes.
Change of bispectral index (BIS)	From the cessation of propofol infusion to extubation, BIS and time (seconds) will be recorded.	After stopping propofol infusion, the BIS and time (seconds) will be recorded and reviewed. These will be recorded for an expected average of 15 minutes.

Trial Locations

Locations (1)

Dept. of anesthesiology and pain medicine, Dongguk University Ilsan Hospital; 🇰🇷 Goyang, Kyunggido, Korea, Republic of