Effect of Dexmedetomidine nebulisation to reduce the blood pressure following Endotracheal intubation.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2022/09/045139
• Lead Sponsor: Dr Deeksha B G

Brief Summary

Direct laryngoscopy and intubation are noxious stimuli and are associated with transient but unpredictable and variable haemodynamic changes. This response occurs within 30 seconds after intubation and lasts less than 10 minutes. The consequences of laryngoscopy and intubation may precipitate ischemia, arrhythmias, cerebrovascular stroke, pulmonary oedema, increase in intracranial pressure in vulnerable group. Till date, numerous drugs and various routes have been tried to attenuate this stress response such as opioids, vasodilators, beta blockers, calcium channel blockers, intravenous lignocaine but none of the agents proved to be ideal.

Dexmedetomidine is a highly selective alpha 2 adrenoreceptor agonist. It is a short acting drug having sympatholytic, sedative, hypnotic, anxiolytic, analgesic and anti-sialogogue properties. Its pleiotropic effect have led to its increasing use for reducing anaesthesia and analgesic requirements in the perioperative period.



The efficacy of dexmedetomidine in attenuating the hemodynamic response to laryngoscopy and intubation has been studied through intravenous, intranasal and intramuscular routes. However, it is noted that intravenous administration causes bradycardia, hypotension and even cardiac arrest [2] and intranasal administration may be associated with nasal irritation, cough, vocal cord irritation or laryngospasm.

Inhalation of nebulized drug is an alternative method of administration that is relatively easy to set up, does not require venipuncture, and is associated with high bioavailability of the administered drug.



Nebulised dexmedetomidine has been used as an effective premedication in paediatric patients in the doses of 1 and 2mcg/kg. Few studies are available which have evaluated either 1 or 2 mcg/kg dexmedetomidine in attenuating stress response to intubation. Hence, our study and we hypothesize that dexmedetomidine nebulisation at 1 mcg/kg provides good haemodynamic stability and sedation.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-09
• Last Update Posted: 2022-08-27

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

All patients posted for surgery under general anaesthesia with Endotracheal intubation.

Exclusion Criteria

Patients with Difficult Airway Pregnancy and Lactation.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study the effect of pre operative dexmedetomidine nebulization on mean arterial pressure following laryngoscopy and intubation	First 5 minutes and 10th minute following laryngoscopy and intubation

Secondary Outcome Measures

Name	Time	Method
Total doses of propofol used	At the time of induction
Changes in the heart rate	Following laryngoscopy and intubation
Sedation score	Pre operatively from the start of nebulization till end of nebulization for every 5 minutes

Trial Locations

Locations (1)

Ot complex; 🇮🇳 Bangalore, KARNATAKA, India

Ot complex

🇮🇳Bangalore, KARNATAKA, India

Dr Deeksha

Principal investigator

9480175763

deekshambbs@gmail.com