Checking the effect of nebulised dexmedetomidine on pulmonary blood pressure in cardiac surgeries

Recruiting

• Registration Number: CTRI/2022/06/043086

Brief Summary

Laryngoscopy and intubation both produce stress response by increasing heart rate, blood pressure, pulmonary artery pressures.

The effect of dexmedetomidine to reduce systemic haemodynamic response during laryngoscopy and intubation is demonstrated in cardiac and non cardiac patients.



Inhalational route has been found to have less systemic effects such as hypotension and bradycardia than intravenous route.



Whether the reduction in pulmonary haemodynamic response during induction is significant or not has not been studied much.



Hypotheses is nebulised dexmedetomidine is more effective in preventing increase in pulmonary artery pressures compared to placebo during laryngoscopy and intubation in cardiac surgery patients.



Primary objective is to compare change in pulmonary artery pressure parameters (pulmonary artery systolic pressure and mean pulmonary artery pressures) during laryngoscopy and intubation between patients receiving dexmedetomidine and placebo nebulisation.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-06
• Last Update Posted: 2023-05-13

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Inclusion Criteria 1.
• Age 18-55 years 2.
• Both genders 3.
• Elective cardiac surgery 4.
• Mitral valve repair or replacement 5.
• Mitral stenosis, mitral regurgitation 6.
• Coronary artery bypass graft with mitral valve replacement.

Exclusion Criteria

• EXCLUSION CRITERIA 1.
• Anticipated difficult airway.
• Preoperative heart rate < 50 bpm 3.
• Uncontrolled AF and ventricular rate 4.
• Second degree heart block and bundle branch blocks 5.
• Right atrial mass or thrombus 7.
• Emergency surgery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compare change in pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressures (mPAP) during laryngoscopy and intubation.	Within 2 successful intubation attempts

Secondary Outcome Measures

Name	Time	Method
Compare PASP and systolic blood pressure (SBP) ratio (PASP/SBP) during laryngoscopy and intubation	every 1 minute of induction of anesthesia till 15 minutes following intubation
Compare PASP, PADP, mPAP, PVR, SBP, DBP, MAP, systemic vascular resistance, cardiac output (CO) and cardiac index (CI)	every 1 minute of induction of anesthesia till 15 minutes following intubation
Compare change in pulmonary vascular resistance (PVR)during laryngoscopes and intubation	every 1 minute of induction of anesthesia till 15 minutes following intubation
Compare dose of propofol and fentanyl required during intubation response to optimise blood pressure	every 1 minute of induction of anesthesia till 15 minutes following intubation
Compare dose of inotropes or vasopressors required	every 1 minute of induction of anesthesia till 15 minutes following intubation

Trial Locations

Locations (1)

AIIMS Rishikesh; 🇮🇳 Dehradun, UTTARANCHAL, India

AIIMS Rishikesh

🇮🇳Dehradun, UTTARANCHAL, India

Dr Shubhdeep Singh

Principal investigator

9463123119

deep494950@gmail.com