“USE OF DEXMEDETOMIDINE TO AVOID CHANGES IN PULSE AND BLOOD PRESSURE DUE TO REMOVAL OF ENDOTRACHEAL TUBE IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANAESTHESIA– PROSPECTIVE, RANDOMIZED STUDY.â€

Not Applicable

Completed

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2018/05/014228
• Lead Sponsor: INDRAPRASTHA APOLLO HOSPITAL NEW DELHI

Brief Summary

Laryngoscopy as well as tracheal intubation in patients undergoing surgery causes significant changes in hemodynamics . A similar type of hemodynamic derangement has been noticed by various workers during tracheal extubation. Various studies have been done on attenuation of extubation response using various drugs. The aim of the study is to define the role of dexmedetomidine with two different doses on attenuation of extubation stress response and hemodynamic changes.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-12
• Study Completion: 2018-11-21
• Last Update Posted: 2022-04-03

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Age 18 – 65yrs 2.
• Either sex.
• Elective cases undergoing abdominal surgeries lasting more than one hour.
• ASA I & ASA II.

Exclusion Criteria

• Patient’s refusal to take part in our study.
• Patient on beta blockers or alpha blockers.
• Patient requiring epidurals for post-operative pain relief.
• Pregnant women.
• Patients with BMI more than 33, those with history of drug abuse or psychological disorder and obese patients, with difficult airway or history of sleep apnoea.
• Age <18 years and >65 years.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.Prevention of rise in blood pressure and heart rate by more than 15% of baseline after injection of Dexmedetomidine 0.50 micro gram per Kg body weight 10 minutes prior to extubation.	2 hour
2.Prevention of rise in blood pressure and heart rate by more than 15% of baseline after injection of Dexmedetomidine 0.25 micro gram per Kg body weight 10 minutes prior to extubation.	2 hour

Secondary Outcome Measures

Name	Time	Method
EXTUBATION TIME	SEDATION SCORE

Trial Locations

Locations (1)

INDRAPRASTHA APOLLO HOSPITAL NEW DELHI; 🇮🇳 South, DELHI, India

INDRAPRASTHA APOLLO HOSPITAL NEW DELHI

🇮🇳South, DELHI, India

DR SANJEEV ANEJA

Principal investigator

9810511510

sanjeevaneja@hotmail.com