To compare the effect of dexmedetomidine drug through two different routes of administration on suppressing intubation response.

Recruiting

• Conditions: Measurement and Monitoring,

• Registration Number: CTRI/2019/04/018416
• Lead Sponsor: Dr Megha V

Brief Summary

Laryngoscopy and endotracheal intubation increase the plasma concentration of catecholamines due to sympathetic stimulation which can result in tachycardia and hypertension in most of the individuals. These changes peaks in 1–2 min and returns to normal levels inside 5-10 minutes after intubation. Dexmedetomidine, a selective α2 receptor agonist, decreases sympathetic tone and has been demonstrated to reduce the stress response to laryngoscopy and intubation when given as a premedication intravenously, but studies related to nebulised dexmedetomidine in attenuation of intubation response are not available. Hence this study is designed to compare the efficacy and safety of  dexmedetomidine through nebulisation route.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-20
• Last Update Posted: 2020-12-18

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients who have given written informed consent 2.
• Patients with ASA grade I & II.
• Patients aged 18-60 years.
• Patients with BMI 19-28 kg/m2 5.
• Patients scheduled for elective surgery under general anaesthesia.

Exclusion Criteria

• Patients not willing to give written informed consent.
• Patients with history of allergy to dexmedetomidine..
• Patients with anticipated difficult mask ventilation/difficult intubation.
• Patients with baseline heart rate < 60 bpm and systolic blood pressure < 100 mm Hg 5.
• Patients with coronary heart disease, ischemic heart disease, heart blocks, diabetes mellitus.
• Pregnant women/Breastfeeding mothers.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Dexmedetomidine nebulisation effectively attenuates pressor response to laryngoscopy and intubation when compared to dexmedetomidine given intravenously , efficacy parameter being hemodynamic parameters ( heart rate, systolic BP, diastolic BP, mean arterial pressures, SpO2	Baseline | Before drug | After drug | Before induction | After induction | Immediate after intubation | 1 min after intubation | 2 min after intubation | 5 min after intubation | 10 min after intubation

Secondary Outcome Measures

Name	Time	Method
dexmedetomidine nebulisation may have lesser side effects like bradycardia, hypotension, dizziness ,post operative sedation etc.	Intra-operative

Trial Locations

Locations (1)

Victoria Hospital under Bangalore Medical college & Research Institute; 🇮🇳 Bangalore, KARNATAKA, India

Victoria Hospital under Bangalore Medical college & Research Institute

🇮🇳Bangalore, KARNATAKA, India

Dr Megha V

Principal investigator

9538481797

meghavenk7692@gmail.com